ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
The timing of dopamine- and noradrenaline-mediated transmission reflects underlying differences in the extent of spillover and pooling.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed.
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- Quantitative anatomy and biophysical modeling of ascending neuromodulatory systems in the developing rat neocortex.PLoS computational biology · 2026Article
- Serotonergic modulation of excitatory synapse development and plasticity.Molecules and cells · 2026Review
- Dynamics of synchronous bursts in functionally coupled midbrain dopamine neurons driven by diverse excitatory inputs.Frontiers in systems neuroscience · 2026Article
- Coding principles of dopaminergic transmission modes.Science advances · 2025Article
- Intrinsic and synaptic regulation of axonal excitability in dopaminergic neurons.Frontiers in cellular neuroscience · 2025Review
- Mechanisms of neuromodulatory volume transmission.Molecular psychiatry · 2024Review
- LC-derived excitatory synaptic transmission to dorsal raphe serotonin neurons is inhibited by activation of alpha2-adrenergic receptors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Neuronomodulation of Excitable Neurons.Neuroscience bulletin · 2024Review
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- Properties and modulation of excitatory inputs to the locus coeruleus.The Journal of physiology · 2022Article
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- Spike-Dependent Dynamic Partitioning of the Locus Coeruleus Network through Noradrenergic Volume Release in a Simulation of the Nucleus Core.Brain sciences · 2022Article
- Effectiveness and Relationship between Biased and Unbiased Measures of Dopamine Release and Clearance.ACS chemical neuroscience · 2022Article
- Divergent properties and independent regulation of striatal dopamine and GABA co-transmission.Cell reports · 2022Article
- Subcellular localization of D2 receptors in the murine substantia nigra.Brain structure & function · 2022Article
- Spatiotemporal Control of Noradrenaline-Dependent Synaptic Transmission in Mouse Dorsal Raphe Serotonin Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Article
- Relationship between regional gray matter volumes and dopamine DHuman brain mapping · 2021Article
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2 authors.
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Abstract
Metabotropic transmission typically occurs through the spillover activation of extrasynaptic receptors. This study examined the mechanisms underlying somatodendritic dopamine and noradrenaline transmission and found that the extent of spillover and pooling varied dramatically between these two transmitters. In the mouse ventral tegmental area, the time course of D2-receptor-mediated IPSCs (D2-IPSCs) was consistent between cells and was unaffected by altering stimulation intensity, probability of release, or the extent of diffusion. Blocking dopamine reuptake with cocaine extended the time course of D2-IPSCs and suggested that transporters strongly limited spillover. As a result, individual release sites contributed independently to the duration of D2-IPSCs. In contrast, increasing the release of noradrenaline in the rat locus ceruleus prolonged the duration of α2-receptor-mediated IPSCs even when reuptake was intact. Spillover and subsequent pooling of noradrenaline activated distal α2-receptors, which prolonged the duration of α2-IPSCs when multiple release sites were activated synchronously. By using the rapid application of agonists onto large macropatches, we determined the concentration profile of agonists underlying the two IPSCs. Incorporating the results into a model simulating extracellular diffusion predicted that the functional range of noradrenaline diffusion was nearly fivefold greater in the locus ceruleus than dopamine in the midbrain. This study demonstrates that catecholamine synapses differentially regulate the extent of spillover and pooling to control the timing of local inhibition and suggests diversity in the roles of uptake and diffusion in governing metabotropic transmission.
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