ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
The selective influence of rhythmic cortical versus cerebellar transcranial stimulation on human physiological tremor.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 55 citations in OpenAlex.
- Transcranial alternating current stimulation for treating spinocerebellar ataxia type 3: A randomized controlled trial.Cell reports. Medicine · 2025Trial
- Using high-amplitude and focused transcranial alternating current stimulation to entrain physiological tremor.Scientific reports · 2018Trial
- What Do We Know About the Influence of the Cerebellum on Walking Ability? Promising Findings from Transcranial Alternating Current Stimulation.Cerebellum (London, England) · 2017Trial
- Alpha and Beta Corticomotor Phase Dynamics Shape Visuomotor Control on a Single-Trial Basis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Tremor pathophysiology.Clinical parkinsonism & related disorders · 2026Review
- Targeting the fundamentals for tremors: the frequency and amplitude coding in essential tremor.Journal of biomedical science · 2025Review
- Transsynaptic modulation of cerebellar nuclear cells: theta AC-burst stimulation.Journal of neural engineering · 2024Article
- Time constraint and error corrections contribute to the increase of hand postural tremor during mental calculation.Heliyon · 2024Article
- Modulation of Cerebellar Nuclear Activity by Transcranial AC Stimulation in Awake Rats.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2024Article
- Transsynaptic entrainment of cerebellar nuclear cells by alternating currents in a frequency dependent manner.Frontiers in neuroscience · 2023Article
- Effects of cerebellar transcranial alternating current stimulation in cerebellar ataxia: study protocol for a randomised controlled trial.Frontiers in neuroscience · 2023Article
- Mental calculation increases physiological postural tremor, but does not influence physiological goal-directed kinetic tremor.European journal of applied physiology · 2022Article
- Interpersonal synchronization of movement intermittency.iScience · 2022Article
- Transcranial direct current stimulation of cerebellum alters spiking precision in cerebellar cortex: A modeling study of cellular responses.PLoS computational biology · 2021Article
- Non-invasive Transcranial Electrical Stimulation in Movement Disorders.Frontiers in neuroscience · 2020Review
- Current challenges: the ups and downs of tACS.Experimental brain research · 2019Review
- tACS motor system effects can be caused by transcutaneous stimulation of peripheral nerves.Nature communications · 2019Article
- Neural Oscillations and the Initiation of Voluntary Movement.Frontiers in psychology · 2018Review
- Guiding transcranial brain stimulation by EEG/MEG to interact with ongoing brain activity and associated functions: A position paper.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2017Review
- Oscillatory Activities in Neurological Disorders of Elderly: Biomarkers to Target for Neuromodulation.Frontiers in aging neuroscience · 2017Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The influence of central neuronal oscillators on human physiological tremor is controversial. To address this, transcranial alternating current stimulation (TACS) was delivered at peak tremor frequency to 12 healthy volunteers in a 2 × 2 crossover study. Two sites were stimulated [contralateral primary motor cortex (M1), vs ipsilateral cerebellum] while participants performed two types of tasks designed to probe the different manifestations of physiological tremor of the hand-kinetic and postural tremor. Tremor was measured by accelerometry. Cortical coherence with the accelerometry signal was also calculated in the absence of stimulation. The phase synchronization index, a measure of the phase entrainment of tremor, was calculated between stimulation and tremor waveforms. The amplitude modulation of tremor was similarly assessed. There was significant phase entrainment that was dependent both on tremor type and site of stimulation: M1 stimulation gave rise to phase entrainment of postural, but not kinetic, tremor, whereas cerebellar stimulation increased entrainment in both cases. There was no effect on tremor amplitude. Tremor accelerometry was shown to be coherent with the cortical EEG recorded during postural, but not kinetic, tremor. TACS modulates physiological tremor, and its effects are dependent both on tremor type and stimulation site. Accordingly, central oscillators play a significant role in two of the major manifestations of tremor in health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.