Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Reinstatement of associative memories in early visual cortex is signaled by the hippocampus.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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Who cites it
83 citing papers in PubMed, 181 citations in OpenAlex.
- Functional connectivity correlates of sequence memory decline in healthy older adults.GeroScience · 2026Article
- Hippocampal mechanisms underlying the resolution of competition in memory and perception.Nature communications · 2026Article
- Deficits in episodic memory and executive functions in relation to CB1 receptor availability in Parkinson's disease.Journal of Parkinson's disease · 2026Article
- Alpha Oscillations Track the Projection of Reactivated Memories into Conscious Awareness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Working Memory Guides Perceptual Decisions Through Fast Capture and Slow Drift.bioRxiv : the preprint server for biology · 2025Article
- Hippocampal-guided reconstruction of an event's prior temporal context.bioRxiv : the preprint server for biology · 2025Article
- Early Visual Cortex Supports One-Shot Episodic Memory via Spatially Tuned Reactivation.bioRxiv : the preprint server for biology · 2025Article
- Replay in the human visual cortex during brief task pauses is linked to implicit learning of successor representations.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Neural evidence that humans reuse strategies to solve new tasks.PLoS biology · 2025Article
- Communication of perceptual predictions from the hippocampus to the deep layers of the parahippocampal cortex.Science advances · 2025Article
- Feedback scales the spatial tuning of cortical responses during both visual working memory and long-term memory.bioRxiv : the preprint server for biology · 2024Article
- Rectified activity-dependent population plasticity implicates cortical adaptation for memory and cognitive functions.Communications biology · 2024Article
- Schema-driven prediction effects on episodic memory across the lifespan.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Memory-related brain potentials for visual objects in early AD show impairment and compensatory mechanisms.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Embodiment in episodic memory through premotor-hippocampal coupling.Communications biology · 2024Article
- Reconstructing Spatiotemporal Trajectories of Visual Object Memories in the Human Brain.eNeuro · 2024Article
- Perception and Memory Reinstatement Engage Overlapping Face-Selective Regions within Human Ventral Temporal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Dynamic predictive coding: A model of hierarchical sequence learning and prediction in the neocortex.PLoS computational biology · 2024Article
- Perception and memory retrieval states are reflected in distributed patterns of background functional connectivity.NeuroImage · 2023Article
- Microstructural and neurochemical plasticity mechanisms interact to enhance human perceptual decision-making.PLoS biology · 2023Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cortical reinstatement hypothesis of memory retrieval posits that content-specific cortical activity at encoding is reinstated at retrieval. Evidence for cortical reinstatement was found in higher-order sensory regions, reflecting reactivation of complex object-based information. However, it remains unclear whether the same detailed sensory, feature-based information perceived during encoding is subsequently reinstated in early sensory cortex and what the role of the hippocampus is in this process. In this study, we used a combination of visual psychophysics, functional neuroimaging, multivoxel pattern analysis, and a well controlled cued recall paradigm to address this issue. We found that the visual information human participants were retrieving could be predicted by the activation patterns in early visual cortex. Importantly, this reinstatement resembled the neural pattern elicited when participants viewed the visual stimuli passively, indicating shared representations between stimulus-driven activity and memory. Furthermore, hippocampal activity covaried with the strength of stimulus-specific cortical reinstatement on a trial-by-trial level during cued recall. These findings provide evidence for reinstatement of unique associative memories in early visual cortex and suggest that the hippocampus modulates the mnemonic strength of this reinstatement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.