ArticleJournal of neurophysiology2014
Neural and genetic degeneracy underlies Caenorhabditis elegans feeding behavior.
Article in Journal of neurophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 65 citations in OpenAlex.
- Article
- Blue-shifted ancyromonad channelrhodopsins for multiplex optogenetics.bioRxiv : the preprint server for biology · 2025Article
- Building and integrating brain-wide maps of nervous system function in invertebrates.Current opinion in neurobiology · 2024Review
- Deciphering the underlying mechanisms of the pharyngeal pumping motions inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Variable task switching in the feeding network ofJournal of neurophysiology · 2023Article
- The enteric nervous system of theeLife · 2022Article
- Article
- System drift and speciation.Evolution; international journal of organic evolution · 2022Article
- Optogenetic Perturbation of Individual C. elegans Pharyngeal Neurons While Monitoring Feeding Behavior.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Cholinergic signaling at the body wall neuromuscular junction distally inhibits feeding behavior in Caenorhabditis elegans.The Journal of biological chemistry · 2022Article
- Perturbation-specific responses by two neural circuits generating similar activity patterns.Current biology : CB · 2021Article
- Article
- Chronic vs acute manipulations reveal degeneracy in a thermosensory neuron network.microPublication biology · 2021Article
- Feeding state functionally reconfigures a sensory circuit to drive thermosensory behavioral plasticity.eLife · 2020Article
- Modular Organization ofGenetics · 2020Article
- Identification of avoidance genes through neural pathway-specific forward optogenetics.PLoS genetics · 2019Article
- Network Degeneracy and the Dynamics of Task Switching in the Feeding Circuit inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Reciprocal modulation of 5-HT and octopamine regulates pumping via feedforward and feedback circuits inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Optical silencing of body wall muscles induces pumping inhibition in Caenorhabditis elegans.PLoS genetics · 2017Article
- Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Degenerate networks, in which structurally distinct elements can perform the same function or yield the same output, are ubiquitous in biology. Degeneracy contributes to the robustness and adaptability of networks in varied environmental and evolutionary contexts. However, how degenerate neural networks regulate behavior in vivo is poorly understood, especially at the genetic level. Here, we identify degenerate neural and genetic mechanisms that underlie excitation of the pharynx (feeding organ) in the nematode Caenorhabditis elegans using cell-specific optogenetic excitation and inhibition. We show that the pharyngeal neurons MC, M2, M4, and I1 form multiple direct and indirect excitatory pathways in a robust network for control of pharyngeal pumping. I1 excites pumping via MC and M2 in a state-dependent manner. We identify nicotinic and muscarinic receptors through which the pharyngeal network regulates feeding rate. These results identify two different mechanisms by which degeneracy is manifest in a neural circuit in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.