ArticleJournal of neurophysiology2014
Acetylcholine functionally reorganizes neocortical microcircuits.
Article in Journal of neurophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- State-space kinetic Ising model reveals task-dependent entropy flow in sparsely active nonequilibrium neuronal dynamics.Nature communications · 2025Article
- Editorial: Neuromodulatory ascending systems: Their influence at the microscopic and macroscopic levels.Frontiers in neural circuits · 2022Article
- Adolescent Ethanol Exposure Alters Cholinergic Function and Apical Dendritic Branching Within the Orbital Frontal Cortex.Neuroscience · 2021Article
- Mechanisms of GABAergic and cholinergic neurotransmission in auditory thalamus: Impact of aging.Hearing research · 2021Review
- Make a Left Turn: Cortico-Striatal Circuitry Mediating the Attentional Control of Complex Movements.Movement disorders : official journal of the Movement Disorder Society · 2021Review
- Neuromodulation of the mind-wandering brain state: the interaction between neuromodulatory tone, sharp wave-ripples and spontaneous thought.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Modulation of cholinergic activity through lynx prototoxins: Implications for cognition and anxiety regulation.Neuropharmacology · 2020Review
- Input dependent modulation of olfactory bulb activity by HDB GABAergic projections.Scientific reports · 2020Article
- Stability of spontaneous, correlated activity in mouse auditory cortex.PLoS computational biology · 2019Article
- Cellular, Synaptic and Network Effects of Acetylcholine in the Neocortex.Frontiers in neural circuits · 2019Review
- Article
- Molecular, Cellular and Circuit Basis of Cholinergic Modulation of Pain.Neuroscience · 2018Review
- New class of reduced computationally efficient neuronal models for large-scale simulations of brain dynamics.Journal of computational neuroscience · 2018Article
- The neuroscience of cognitive-motivational styles: Sign- and goal-trackers as animal models.Behavioral neuroscience · 2018Article
- Ensemble stacking mitigates biases in inference of synaptic connectivity.Network neuroscience (Cambridge, Mass.) · 2018Article
- Article
- Dysfunctional Sensory Modalities, Locus Coeruleus, and Basal Forebrain: Early Determinants that Promote Neuropathogenesis of Cognitive and Memory Decline and Alzheimer's Disease.Neurotoxicity research · 2016Review
- Review
- Spontaneous activations follow a common developmental course across primary sensory areas in mouse neocortex.Journal of neurophysiology · 2016Article
- Higher-Order Synaptic Interactions Coordinate Dynamics in Recurrent Networks.PLoS computational biology · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Sensory information is processed and transmitted through the synaptic structure of local cortical circuits, but it is unclear how modulation of this architecture influences the cortical representation of sensory stimuli. Acetylcholine (ACh) promotes attention and arousal and is thought to increase the signal-to-noise ratio of sensory input in primary sensory cortices. Using high-speed two-photon calcium imaging in a thalamocortical somatosensory slice preparation, we recorded action potential activity of up to 900 neurons simultaneously and compared local cortical circuit activations with and without bath presence of ACh. We found that ACh reduced weak pairwise relationships and excluded neurons that were already unreliable during circuit activity. Using action potential activity from the imaged population, we generated functional wiring diagrams based on the statistical dependencies of activity between neurons. ACh pruned weak functional connections from spontaneous circuit activations and yielded a more modular and hierarchical circuit structure, which biased activity to flow in a more feedforward fashion. Neurons that were active in response to thalamic input had reduced pairwise dependencies overall, but strong correlations were conserved. This coincided with a prolonged period during which neurons showed temporally precise responses to thalamic input. Our results demonstrate that ACh reorganizes functional circuit structure in a manner that may enhance the integration and discriminability of thalamic afferent input within local neocortical circuitry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.