ArticleClinical and vaccine immunology : CVI2014
Macrophage depletion prior to Neospora caninum infection results in severe neosporosis in mice.
Article in Clinical and vaccine immunology : CVI, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Deferiprone Modulates Ferroptosis to Protect Macrophages and Liver during Neospora caninum Infection.Acta parasitologica · 2026Article
- Mitochondrial damage and IL-1β production in monocytes caused byFrontiers in immunology · 2025Article
- Mouse innate resistance tomSphere · 2024Article
- Whole-transcriptome analysis reveals virulence-specific pathogen-host interactions at the placenta in bovine neosporosis.Frontiers in immunology · 2023Article
- Exploiting the Macrophage Production of IL-12 in Improvement of Vaccine Development againstVaccines · 2022Review
- Neospora caninum inhibits tumor development by activating the immune response and destroying tumor cells in a B16F10 melanoma model.Parasites & vectors · 2022Article
- Neospora caninum infection induces an isolate virulence-dependent pro-inflammatory gene expression profile in bovine monocyte-derived macrophages.Parasites & vectors · 2020Article
- From Signaling Pathways to Distinct Immune Responses: Key Factors for Establishing or CombatingPathogens (Basel, Switzerland) · 2020Review
- Differential Responses of Bovine Monocyte-Derived Macrophages to Infection byFrontiers in immunology · 2019Article
- Neospora caninum Dense Granule Protein 7 Regulates the Pathogenesis of Neosporosis by Modulating Host Immune Response.Applied and environmental microbiology · 2018Article
- NLRP3 Inflammasome Participates in Host Response toFrontiers in immunology · 2018Article
- NLRP3 inflammasome activation in murine macrophages caused by Neospora caninum infection.Parasites & vectors · 2017Article
- Bovine Polymorphonuclear Neutrophils Cast Neutrophil Extracellular Traps against the Abortive ParasiteFrontiers in immunology · 2017Article
- Changes in neurotransmitter levels and expression of immediate early genes in brain of mice infected with Neospora caninum.Scientific reports · 2016Article
- Predominant role of interferon-γ in the host protective effect of CD8(+) T cells against Neospora caninum infection.Scientific reports · 2015Article
- Immune response in the adipose tissue of lean mice infected with the protozoan parasite Neospora caninum.Immunology · 2015Article
- Role of the chemokine receptor CCR5-dependent host defense system in Neospora caninum infections.Parasites & vectors · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We observed that murine macrophages showed greater activation and increased interleukin 6 (IL-6), IL-12p40, and interferon gamma (IFN-γ) production during Neospora caninum infection. Many macrophages migrated to the site of infection. Furthermore, macrophage-depleted mice exhibited increased sensitivity to N. caninum infection. This study indicates that macrophages are required for achieving protective immunity against N. caninum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.