ArticleJournal of the Royal Society, Interface2014
Modelling and analysis of bacterial tracks suggest an active reorientation mechanism in Rhodobacter sphaeroides.
Article in Journal of the Royal Society, Interface, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Approximate Solutions of a General Stochastic Velocity-Jump Model Subject to Discrete-Time Noisy Observations.Bulletin of mathematical biology · 2025Article
- Swimming Using a Unidirectionally Rotating, Single Stopping Flagellum in the Alpha ProteobacteriumFrontiers in microbiology · 2022Review
- Origins of eukaryotic excitability.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- The swimming of a deforming helix.The European physical journal. E, Soft matter · 2018Article
- Bacterial Biohybrid Microswimmers.Frontiers in robotics and AI · 2018Review
- Light-controlled motility in prokaryotes and the problem of directional light perception.FEMS microbiology reviews · 2017Review
- Structural Characterization of the Fla2 Flagellum of Rhodobacter sphaeroides.Journal of bacteriology · 2015Article
- Emergent stem cell homeostasis in the C. elegans germline is revealed by hybrid modeling.Biophysical journal · 2015Article
- From Birds to Bacteria: Generalised Velocity Jump Processes with Resting States.Bulletin of mathematical biology · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most free-swimming bacteria move in approximately straight lines, interspersed with random reorientation phases. A key open question concerns varying mechanisms by which reorientation occurs. We combine mathematical modelling with analysis of a large tracking dataset to study the poorly understood reorientation mechanism in the monoflagellate species Rhodobacter sphaeroides. The flagellum on this species rotates counterclockwise to propel the bacterium, periodically ceasing rotation to enable reorientation. When rotation restarts the cell body usually points in a new direction. It has been assumed that the new direction is simply the result of Brownian rotation. We consider three variants of a self-propelled particle model of bacterial motility. The first considers rotational diffusion only, corresponding to a non-chemotactic mutant strain. Two further models incorporate stochastic reorientations, describing 'run-and-tumble' motility. We derive expressions for key summary statistics and simulate each model using a stochastic computational algorithm. We also discuss the effect of cell geometry on rotational diffusion. Working with a previously published tracking dataset, we compare predictions of the models with data on individual stopping events in R. sphaeroides. This provides strong evidence that this species undergoes some form of active reorientation rather than simple reorientation by Brownian rotation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.