ArticleProceedings of the National Academy of Sciences of the United States of America2014
Functional magnetic resonance microscopy at single-cell resolution in Aplysia californica.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Validity and specificity of BOLD effects and their correction inFrontiers in neuroscience · 2024Article
- Review
- Elucidating the complex organization of neural micro-domains in the locust Schistocerca gregaria using dMRI.Scientific reports · 2021Article
- Isotropic 25-Micron 3D Neuroimaging UsingFrontiers in neural circuits · 2018Article
- Structural Features of Europium(II)-Containing Cryptates That Influence Relaxivity.Chemistry (Weinheim an der Bergstrasse, Germany) · 2017Article
- Direct detection of neural activity in vitro using magnetic resonance electrical impedance tomography (MREIT).NeuroImage · 2017Article
- Modulation of water diffusion by activation-induced neural cell swelling in Aplysia Californica.Scientific reports · 2017Article
- Spectroscopic Characterization of the 3+ and 2+ Oxidation States of Europium in a Macrocyclic Tetraglycinate Complex.Inorganic chemistry · 2016Article
- A Eu(II)-Containing Cryptate as a Redox Sensor in Magnetic Resonance Imaging of Living Tissue.Angewandte Chemie (International ed. in English) · 2015Article
- Information processing in the CNS: a supramolecular chemistry?Cognitive neurodynamics · 2015Review
- Overcoming the concentration-dependence of responsive probes for magnetic resonance imaging.Metallomics : integrated biometal science · 2015Review
- Oxidation-responsive Eu(2+/3+)-liposomal contrast agent for dual-mode magnetic resonance imaging.Chemical communications (Cambridge, England) · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this work, we show the feasibility of performing functional MRI studies with single-cell resolution. At ultrahigh magnetic field, manganese-enhanced magnetic resonance microscopy allows the identification of most motor neurons in the buccal network of Aplysia at low, nontoxic Mn(2+) concentrations. We establish that Mn(2+) accumulates intracellularly on injection into the living Aplysia and that its concentration increases when the animals are presented with a sensory stimulus. We also show that we can distinguish between neuronal activities elicited by different types of stimuli. This method opens up a new avenue into probing the functional organization and plasticity of neuronal networks involved in goal-directed behaviors with single-cell resolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.