ArticleAmerican journal of physiology. Renal physiology2014
High-salt diet blunts renal autoregulation by a reactive oxygen species-dependent mechanism.
Article in American journal of physiology. Renal physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 54 citations in OpenAlex.
- High dietary salt intake increases urinary NGAL excretion and creatinine clearance in healthy young adults.American journal of physiology. Renal physiology · 2022Trial
- Global burden and trends of chronic kidney disease due to type 2 diabetes mellitus caused by dietary risks: insights from the global burden of disease study 2021.Frontiers in endocrinology · 2025Article
- Endothelial histone deacetylase 1 activity impairs kidney microvascular NO signaling in rats fed a high-salt diet.Acta physiologica (Oxford, England) · 2024Article
- Linear Correlation Between Mean Arterial Pressure and Urine Output in Critically Ill Patients.Critical care explorations · 2024Observational
- Global, regional, and national burden of chronic kidney disease attributable to high sodium intake from 1990 to 2019.Frontiers in nutrition · 2023Article
- Effect of Mineral-Balanced Deep-Sea Water on Kidney Function and Renal Oxidative Stress Markers in Rats Fed a High-Salt Diet.International journal of molecular sciences · 2021Article
- Current Understanding of Pressure Natriuresis.Electrolyte & blood pressure : E & BP · 2021Review
- Transcriptome sequencing reveals high-salt diet-induced abnormal liver metabolic pathways in mice.BMC gastroenterology · 2021Article
- Restoration of afferent arteriolar autoregulatory behavior in ischemia-reperfusion injury in rat kidneys.American journal of physiology. Renal physiology · 2021Article
- The Role of the Renal Dopaminergic System and Oxidative Stress in the Pathogenesis of Hypertension.Biomedicines · 2021Review
- High salt exacerbates acute kidney injury by disturbing the activation of CD5L/apoptosis inhibitor of macrophage (AIM) protein.PloS one · 2021Article
- Role for ovarian hormones in purinoceptor-dependent natriuresis.Biology of sex differences · 2020Article
- Endurance exercise protects agingBiology open · 2020Article
- Body Fluid-Independent Effects of Dietary Salt Consumption in Chronic Kidney Disease.Nutrients · 2019Review
- Diet and Chronic Kidney Disease.Advances in nutrition (Bethesda, Md.) · 2019Review
- Antagonism of major histocompatibility complex class II invariant chain peptide during chronic lipopolysaccharide treatment rescues autoregulatory behavior.American journal of physiology. Renal physiology · 2019Article
- High-Salt Loading Downregulates Nrf2 Expression in a Sodium-Dependent Manner in Renal Collecting Duct Cells.Frontiers in physiology · 2019Article
- Renal autoregulation and blood pressure management in circulatory shock.Critical care (London, England) · 2018Review
- Mechanisms of sphingosine-1-phosphate-mediated vasoconstriction of rat afferent arterioles.Acta physiologica (Oxford, England) · 2018Article
- Acute toll-like receptor 4 activation impairs rat renal microvascular autoregulatory behaviour.Acta physiologica (Oxford, England) · 2017Article
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6 authors at 1 institution in 1 country.
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Abstract
High dietary salt is common in Western countries and is an important contributor to increased cardiovascular disease. Autoregulation of renal blood flow (RBF) and glomerular filtration rate (GFR) is an essential function of the renal microcirculation that could be affected by excessive dietary salt. High salt (HS) increases renal ROS generation partly by the enzyme NADPH oxidase. We hypothesized that a HS diet would impair autoregulation via NADPH oxidase-dependent ROS generation. The role of NADPH-dependent ROS production on the blunted autoregulatory response with a HS diet was assessed in vitro and in vivo using the blood-perfused juxtamedullary nephron preparation and anesthetized rats, respectively. The increase in renal lipid peroxidation and p67(phox) expression induced by HS was prevented by apocynin treatment. Control afferent arterioles exhibited normal autoregulatory behavior in response to acute increases in renal perfusion pressure, whereas arterioles from HS rats exhibited a blunted response. Autoregulatory behavior in HS rats was restored in vitro by acute exposure to the NADPH oxidase inhibitor apocynin. At the whole kidney level, in vivo experiments showed that both RBF and GFR declined in HS rats when left kidney renal perfusion pressure was reduced from ambient to 95 mmHg, whereas control rats maintained stable GFR and RBF consistent with efficient autoregulatory behavior. Apocynin treatment improved in vivo autoregulatory behavior in HS rats and had no detectable effect in normal salt diet-fed rats. These data support the hypothesis that impaired renal autoregulatory behavior in rats fed a HS diet is mediated by NADPH oxidase-derived ROS.
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