ArticleCerebellum (London, England)2014
Normal motor adaptation in cervical dystonia: a fundamental cerebellar computation is intact.
Article in Cerebellum (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Comparison of Oropharyngeal Dysphagia Before and After Botulinum Toxin Injection in Cervical Dystonia.Dysphagia · 2023Article
- Neuromodulation in Dystonia - Harnessing the Network.Advances in neurobiology · 2023Article
- Dystonia in Childhood: How Insights from Paediatric Research Enrich the Network Theory of Dystonia.Advances in neurobiology · 2023Article
- A Critical Investigation of Cerebellar Associative Learning in Isolated Dystonia.Movement disorders : official journal of the Movement Disorder Society · 2022Article
- Impaired Saccade Adaptation in Tremor-Dominant Cervical Dystonia-Evidence for Maladaptive Cerebellum.Cerebellum (London, England) · 2021Article
- A narrative review on non-invasive stimulation of the cerebellum in neurological diseases.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Review
- Contemporary clinical neurophysiology applications in dystonia.Journal of neural transmission (Vienna, Austria : 1996) · 2021Review
- Tremor-Dominant Cervical Dystonia: a Cerebellar Syndrome.Cerebellum (London, England) · 2021Article
- Motor learning deficits in cervical dystonia point to defective basal ganglia circuitry.Scientific reports · 2021Article
- The Use of Botulinum Toxin for Treatment of the Dystonias.Handbook of experimental pharmacology · 2021Article
- Delineating the electrophysiological signature of dystonia.Experimental brain research · 2020Review
- Sensory trick phenomenon in cervical dystonia: a functional MRI study.Journal of neurology · 2020Article
- Advances in the pathophysiology of adult-onset focal dystonias: recent neurophysiological and neuroimaging evidence.F1000Research · 2020Review
- Network localization of cervical dystonia based on causal brain lesions.Brain : a journal of neurology · 2019Article
- Sensorimotor Control in Dystonia.Brain sciences · 2019Review
- Abnormal cerebellar processing of the neck proprioceptive information drives dysfunctions in cervical dystonia.Scientific reports · 2018Article
- The Anatomical Basis for Dystonia: The Motor Network Model.Tremor and other hyperkinetic movements (New York, N.Y.) · 2017Review
- Cerebellum: An explanation for dystonia?Cerebellum & ataxias · 2017Review
- Article
- Effects of cerebellar theta-burst stimulation on arm and neck movement kinematics in patients with focal dystonia.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2016Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
The potential role of the cerebellum in the pathophysiology of dystonia has become a focus of recent research. However, direct evidence for a cerebellar contribution in humans with dystonia is difficult to obtain. We examined motor adaptation, a test of cerebellar function, in 20 subjects with primary cervical dystonia and an equal number of aged matched controls. Adaptation to both visuomotor (distorting visual feedback by 30°) and forcefield (applying a velocity-dependent force) conditions were tested. Our hypothesis was that cerebellar abnormalities observed in dystonia research would translate into deficits of cerebellar adaptation. We also examined the relationship between adaptation and dystonic head tremor as many primary tremor models implicate the cerebellothalamocortical network which is specifically tested by this motor paradigm. Rates of adaptation (learning) in cervical dystonia were identical to healthy controls in both visuomotor and forcefield tasks. Furthermore, the ability to adapt was not clearly related to clinical features of dystonic head tremor. We have shown that a key motor control function of the cerebellum is intact in the most common form of primary dystonia. These results have important implications for current anatomical models of the pathophysiology of dystonia. It is important to attempt to progress from general statements that implicate the cerebellum to a more specific evidence-based model. The role of the cerebellum in this enigmatic disease perhaps remains to be proven.
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Registered trials
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