ArticleInternational wound journal2016
VAC therapy to promote wound healing after surgical revascularisation for critical lower limb ischaemia.
Article in International wound journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Comparison of Indigenous Low Cost Vacuum-Assisted Closure Therapy and Standard Wound Therapy in Open Fractures: A Randomized Controlled Trial.Journal of orthopaedic case reports · 2026Article
- Peripheral Prosthetic Vascular Graft Infection: A 5-Year Retrospective Study.Medical sciences (Basel, Switzerland) · 2025Article
- Negative-Pressure Wound Therapy: What We Know and What We Need to Know.Advances in experimental medicine and biology · 2023Article
- Fatty acid potassium improves human dermal fibroblast viability and cytotoxicity, accelerating human epidermal keratinocyte wound healing in vitro and in human chronic wounds.International wound journal · 2021Article
- A multistage combined approach to promote diabetic wound healing in COVID-19 era.International wound journal · 2020Article
- Local release of metalloproteinases and their inhibitors after a successful revascularisation procedure.International wound journal · 2020Article
- Different inflammatory cytokines release after open and endovascular reconstructions influences wound healing.International wound journal · 2019Article
- Inflammatory biomarkers, vascular procedures of lower limbs, and wound healing.International wound journal · 2019Article
- VAC therapy for the treatment of complex wounds after cardio-thoracic surgery.International wound journal · 2016Article
- Matrix metalloproteinases and risk stratification in patients undergoing surgical revascularisation for critical limb ischaemia.International wound journal · 2016Article
- Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vacuum-assisted closure (VAC) therapy is a new emerging non-invasive system in wound care, which speeds up wound healing by causing vacuum, improving tissue perfusion and suctioning the exudates, and facilitating the removal of bacteria from the wound. The application of sub-atmospheric pressure on the lesions seems to alter the cytoskeleton of the cells on the wound bed, triggering a cascade of intracellular signals that increase the rate of cell division and subsequent formation of granulation tissue. The aim of this study is to analyse the results of VAC therapy used as an adjuvant therapy for the treatment of foot wounds in patients affected by critical limb ischaemia (CLI) (Rutherford 6 class) after distal surgical revascularisation, to promote and accelerate the healing of ulcers. Twenty-nine patients (20 males, 9 females; mean age 68·4) affected by CLI of Rutherford 6 class, after surgical revascularisation of the lower limb, underwent VAC therapy in order to speed up wound healing. Complete wound healing was achieved in 19 patients (65·51%), in an average period of 45·4 ± 25·6 days. VAC therapy is a valid aid, after surgical revascularisation, to achieve rapid healing of foot lesions in patients with CLI.
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