Evidence map›Paper›PMID 24872120›Full record

ArticleBiological research for nursing2015

Cytokine gene associations with self-report ratings of morning and evening fatigue in oncology patients and their family caregivers.

Anand Dhruva, Bradley E Aouizerat, Bruce Cooper, Steven M Paul, Marylin Dodd, Claudia West, William Wara, Kathryn Lee, Laura B Dunn, Dale J Langford and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological research for nursing, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Cancer symptom cluster research in pediatric oncology: a work in progress.Exploration of targeted anti-tumor therapy · 2024
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Impact of worst pain severity and morning fatigue profiles on oncology outpatients' symptom burden and quality of life.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Article
  13. Article
  14. Article
  15. Article
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  18. Article
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Anand DhruvaSchool of Medicine, University of California, San Francisco, CA, USA.
Bradley E AouizeratSchool of Nursing, University of California, San Francisco, CA, USA Institute for Human Genetics, University of California, San Francisco, CA, USA.
Bruce CooperSchool of Nursing, University of California, San Francisco, CA, USA.
Steven M PaulSchool of Nursing, University of California, San Francisco, CA, USA.
Marylin DoddSchool of Nursing, University of California, San Francisco, CA, USA.
Claudia WestSchool of Nursing, University of California, San Francisco, CA, USA.
William WaraKaiser Permanente, San Francisco, CA, USA.
Kathryn LeeSchool of Nursing, University of California, San Francisco, CA, USA.
Laura B DunnSchool of Medicine, University of California, San Francisco, CA, USA.
Dale J LangfordSchool of Nursing, University of California, San Francisco, CA, USA.
John D MerrimanSchool of Nursing, University of California, San Francisco, CA, USA.
Christina BaggottSchool of Nursing, University of California, San Francisco, CA, USA.
Janine CataldoSchool of Nursing, University of California, San Francisco, CA, USA.
Christine RitchieSchool of Medicine, University of California, San Francisco, CA, USA.
Kord M KoberSchool of Nursing, University of California, San Francisco, CA, USA.
Heather LeutwylerSchool of Nursing, University of California, San Francisco, CA, USA.
Christine MiaskowskiSchool of Nursing, University of California, San Francisco, CA, USA chris.miaskowski@nursing.ucsf.edu.
University of California, San Francisco · USKaiser Permanente San Francisco Medical Center · US

Funding

FATIGUE, PAIN, AND SLEEP PROBLEMS DURING RADIATIONR01NR004835 · NINR · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI MIASKOWSKI, CHRISTINE A. · 1999 to 2002
$2.2M
A Whole Systems Approach to the Study of Ayurveda for Cancer SurvivorshipK23AT005340 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DHRUVA, ANAND · 2009 to 2013
$635k
Identification of Genetic Markers Associated With Attentional FatigueF31NR012604 · NINR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MERRIMAN, JOHN D. · 2010 to 2013
$95k
NCCIH NIH HHS K23 AT005340NCRR NIH HHS KL2 RR624130NCRR NIH HHS RR624130NINR NIH HHS F31 NR012604NINR NIH HHS NR04835NINR NIH HHS R01 NR004835
6 · The paper itself

Abstract

The purpose of this study was to evaluate for differences in variations in pro- and anti-inflammatory cytokine genes between participants who were classified as having low and high levels of morning and evening fatigue and to evaluate for differences in phenotypic characteristics between these two groups. In a sample of 167 oncology outpatients with breast, prostate, lung, or brain cancer and 85 of their family caregivers, growth mixture modeling was used to identify latent classes of individuals based on ratings of morning and evening fatigue obtained prior to, during, and for 4 months following completion of radiation therapy. Differences in single nucleotide polymorphisms and haplotypes in 15 cytokine genes were evaluated between the latent classes. Multiple logistic regression was used to assess the effect of phenotypic and genotypic characteristics on morning and evening fatigue class membership. Associations were found between morning fatigue and number of comorbidities as well as variations in tumor necrosis factor alpha (TNFA) rs1800629 and rs3093662. Evening fatigue was associated with caring for children at home and variations in interleukin 4 (IL4) rs2243248 and TNFA rs2229094. Younger age and lower performance status were associated with both morning and evening fatigue. These findings suggest that inflammatory mediators are associated with the development of morning and evening fatigue. However, because different phenotypic characteristics and genomic markers are associated with diurnal variations in fatigue, morning and evening fatigue may be distinct but related symptoms.

Indexed as

CaregiversCytokinesFatigueFemaleGenetic Association StudiesGenetic MarkersHaplotypesHumansMaleMiddle AgedNeoplasmsPhenotypePolymorphism, GeneticPolymorphism, Single NucleotideRegression AnalysisTimeCytokinesGenetic Markersbreast cancercytokinesevening fatiguegeneticsinterleukin 4morning fatiguetumor necrosis factor alpha

Identifiers

PMID24872120
PMCPMC5486216
OpenAlexW2148870299

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.