ArticleDrug safety2014
Association between use of multiple psychoactive medicines and hospitalization for falls: retrospective analysis of a large healthcare claim database.
Article in Drug safety, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Exploring Population Characteristics and Recruitment Challenges in Older People Experiencing Falls at Home without Hospitalization or with an Emergency Department Visit: Insights from the RISING-DOM Experience.Clinical interventions in aging · 2023Trial
- Concurrent use of medicines with similar adverse drug reaction profiles in older adults: identifying potential deprescribing opportunities using population-level dispensing data.International journal of clinical pharmacy · 2026Article
- Use of, time to, and type of first add-on anti-hyperglycaemic therapy to metformin in Australia, 2018-2022.British journal of clinical pharmacology · 2025Article
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- Article
- Risk of Fall-Related Injuries Associated with Antidepressant Use in Elderly Patients: A Nationwide Matched Cohort Study.International journal of environmental research and public health · 2022Article
- Change in central nervous system-active medication use following fall-related injury in older adults.Journal of the American Geriatrics Society · 2022Article
- Association Between Medications Acting on the Central Nervous System and Fall-Related Injuries in Community-Dwelling Older Adults: A New User Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Association of benzodiazepines, opioids and tricyclic antidepressants use and falls in trauma patients: Conditional effect of age.PloS one · 2020Article
- Psychoactive drug use and falls among community-dwelling Turkish older people.Northern clinics of Istanbul · 2020Article
- Article
- Willingness to Change Medications Linked to Increased Fall Risk: A Comparison between Age Groups.Journal of the American Geriatrics Society · 2019Article
- The interplay of context factors in hypnotic and sedative prescription in primary and secondary care-a qualitative study.European journal of clinical pharmacology · 2019Article
- Reducing hypnotic use in insomnia management among Australian veterans: results from repeated national interventions.BMC health services research · 2018Article
- Record of the circumstances of falls in the community: perspective in the Iberian Peninsula.Revista latino-americana de enfermagem · 2018Article
- Psychotropic polypharmacy in Australia, 2006 to 2015: a descriptive cohort study.British journal of clinical pharmacology · 2017Article
- Medication Use and Fall-Related Hospital Admissions from Long-Term Care Facilities: A Hospital-Based Case-Control Study.Drugs & aging · 2017Article
- A methodological protocol for selecting and quantifying low-value prescribing practices in routinely collected data: an Australian case study.Implementation science : IS · 2017Article
- Assessment of risk of falls in elderly living at home.Revista latino-americana de enfermagem · 2017Article
- Elderly patients treated with psychotropic medicines admitted to hospital: associated characteristics and inappropriate use.European journal of clinical pharmacology · 2016Observational
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLittle is known about the impact of taking multiple psychoactive medicines on the risk of hospitalization for falls.
objectiveTo identify the association between multiple psychoactive medicine use and hospitalization for falls.
methodsA retrospective cohort study was conducted between July 2011 and June 2012 in the Australian veteran population who had been dispensed at least one psychoactive medicine within the previous year. Psychoactive medicines with sedative properties included antipsychotics, anxiolytics, hypnotics, antidepressants, opioids, anti-epileptics, anti-Parkinson medicines and medicines for migraine. The associations between falls and the number of psychoactive medicines used or the number of doses were analysed in comparison with falls that occurred when no psychoactive medicine was used.
resultsThe adjusted results showed a significantly increased risk of falls when patients were on one or more psychoactive medicines or were receiving 0.1-0.9 defined daily dose (DDD) or more per day. The incident rate ratios (IRRs) were 1.22 (95% confidence interval [CI] 1.08-1.38) for those on one psychoactive medicine, 1.70 (95% CI 1.45-1.99) for those on two, 1.96 (95% CI 1.58-2.43) for those on three or four, and 3.15 (95% CI 1.90-5.23) for those on five or more. A similar result was observed when the data were analysed by dose, with the highest risk being found for those taking three or more DDD per day (adjusted IRR 4.26, 95% CI 2.75-6.58).
conclusionIncreased numbers or increased doses of psychoactive medicines are associated with an increased risk of hospitalization for falls in older adults. Strategies to reduce the psychoactive medicine burden are likely to translate into significant health benefits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.