Evidence map›Paper›PMID 24872009›Full record

ArticleExpert review of vaccines2014

Could moderate alcohol intake be recommended to improve vaccine responses?

Ilhem Messaoudi, Sumana Pasala, Kathleen Grant

Open access · bronzeAbstract readEditorial
In one paragraph

Article in Expert review of vaccines, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. How does geographical diversity shape vaccine efficacy?Clinical and experimental vaccine research · 2024
    Review
  2. Vaccinomics and adversomics: key elements for a personalized vaccinology.Clinical and experimental vaccine research · 2024
    Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Psychosocial Vulnerabilities to Upper Respiratory Infectious Illness: Implications for Susceptibility to Coronavirus Disease 2019 (COVID-19).Perspectives on psychological science : a journal of the Association for Psychological Science · 2021
    Article
  8. Article
  9. Article
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Ilhem MessaoudiDivision of Biomedical Sciences, School of Medicine, University of California-Riverside, Riverside, CA 92521, USA.
Sumana Pasala
Kathleen Grant
University of California, Riverside · USOregon Health & Science University · US

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
Stress and Ethanol Self-Administration in MonkeysU01AA013510 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KATHLEEN A GRANT · 2002 to 2026
$11.8M
Monkey Alcohol Tissue Research Resource (MATRR)R24AA019431 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Mary Lauren Benton, Verginia Carmella Cuzon Carlson · 2010 to 2026
$10.3M
INIA: Stress, Anxiety of Alcohol AbuseU01AA013641 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI GRANT, KATHLEEN A · 2002 to 2015
$8.8M
Impact of chronic ethanol self administration on T cellR21AA021947 · NIAAA · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI MESSAOUDI, ILHEM · 2013 to 2014
$394k
NIAAA NIH HHS R21 AA021947NIAAA NIH HHS R21AA021947NIAAA NIH HHS R24 AA019431NIAAA NIH HHS U01 AA013510NIAAA NIH HHS U01 AA013641NIAAA NIH HHS U01 AA13510NIAAA NIH HHS U01 AA13641NIH HHS 8P51 OD011092-53NIH HHS P51 OD011092
6 · The paper itself

Abstract

The impact of alcohol consumption on human health is complex and modulated by several factors such as patterns and amount of drinking, genetics, the organ system studied, as well as the sex and age of the user. There is strong evidence that chronic ethanol abuse is associated with increased morbidity and mortality, immunosuppression and increased susceptibility to both bacterial and viral infections. In contrast, moderate alcohol consumption exerts positive effects including decreased mortality, and improved cardiovascular disease and insulin sensitivity. Interestingly, accumulating evidence also supports an immune-boosting effect of moderate alcohol. In this editorial, we summarize the findings that support a positive effect of moderate alcohol on host immunity. We also discuss the limitations of the previous data and emphasize the importance of additional studies to uncover mechanisms for these immune-stimulating effects in order to extend these benefits to vulnerable segments of the population who cannot consume alcohol.

Indexed as

AdiponectinAlcohol Drinkingalpha 1-AntitrypsinAnimalsAntibody FormationCD8-Positive T-LymphocytesCell Adhesion MoleculesCommon ColdC-Reactive ProteinCytokinesDisease SusceptibilityEthanolFerritinsFibrinogenHumansHypersensitivity, DelayedAdiponectinalpha 1-AntitrypsinCell Adhesion MoleculesC-Reactive ProteinCytokinesEthanolFerritinsFibrinogenVaccinesalcoholimmunityinflammationmacaquevaccine

Identifiers

PMID24872009
PMCPMC4245072
OpenAlexW2167423823

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.