Evidence map›Paper›PMID 24871944›Full record

ArticleDevelopmental cell2014

Genome stress response in early development.

William F Marzluff, Robert J Duronio

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

William F MarzluffDepartment of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA; Integrative Program for Biological and Genome Sciences, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: william_marzluff@med.unc.edu.
Robert J DuronioDepartments of Biology and Genetics, University of North Carolina, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA; Integrative Program for Biological and Genome Sciences, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: duronio@med.unc.edu.

Funding

HISTONE MRNA REGULATION IN DEVELOPMENTR01GM058921 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DURONIO, ROBERT J, MARZLUFF, WILLIAM F. · 1999 to 2025
$11.6M
Engineering histone genes to interrogate the epigenetic code in space and timeR01DA036897 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DURONIO, ROBERT J, MATERA, A. GREGORY · 2013 to 2017
$2.2M
NIDA NIH HHS R01 DA036897NIGMS NIH HHS R01 GM058921
6 · The paper itself

Abstract

Cells with irreparable genomic damage pose a problem for development and must be eliminated to prevent disease. Reporting in this issue of Developmental Cell, Iampietro et al. (2014) describe a mechanism in Drosophila that removes damaged nuclei from syncytial blastoderm embryos via DNA damage checkpoint kinase-mediated retention of specific mRNAs within the nucleus.

Indexed as

AnimalsCell NucleusCheckpoint Kinase 2Drosophila melanogasterDrosophila ProteinsRNA-Binding ProteinsCheckpoint Kinase 2Drosophila Proteinslok protein, DrosophilaRNA-Binding ProteinsSLBP protein, Drosophila

Identifiers

PMID24871944
PMCPMC4107455

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.