ArticleGenes and immunity2014
The CLRX.1/NOD24 (NLRP2P) pseudogene codes a functional negative regulator of NF-κB, pyrin-only protein 4.
Article in Genes and immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Comprehensive Analysis of IgA Nephropathy Causal Factors in Plasma Proteins, Immune Cell Types, and Immune Cell Traits.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- The ASC-c isoform as a modulator of inflammasome activation: Insights into molecular mechanisms and therapeutic applications.The Journal of biological chemistry · 2026Article
- New Insights on NLRP3 Inflammasome: Mechanisms of Activation, Inhibition, and Epigenetic Regulation.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2024Review
- NOD1, NOD2, PYDC1, and PYDC2 gene polymorphisms in ovarian endometriosis.Frontiers in medicine · 2024Article
- POP1 inhibits MSU-induced inflammasome activation and ameliorates gout.Frontiers in immunology · 2022Article
- Inflammasome activation: from molecular mechanisms to autoinflammation.Clinical & translational immunology · 2022Review
- Article
- An Update on CARD Only Proteins (COPs) and PYD Only Proteins (POPs) as Inflammasome Regulators.International journal of molecular sciences · 2020Review
- Molecular fossils "pseudogenes" as functional signature in biological system.Genes & genomics · 2020Review
- Re-recognition of pseudogenes: From molecular to clinical applications.Theranostics · 2020Review
- Pseudogenes in Cardiovascular Disease.Frontiers in molecular biosciences · 2020Review
- COPs and POPs Patrol Inflammasome Activation.Journal of molecular biology · 2018Review
- Network analysis of pseudogene-gene relationships: from pseudogene evolution to their functional potentials.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2018Article
- Pyrin-only protein 2 limits inflammation but improves protection against bacteria.Nature communications · 2017Article
- Assembly and regulation of ASC specks.Cellular and molecular life sciences : CMLS · 2017Review
- Pseudogenes regulate parental gene expression via ceRNA network.Journal of cellular and molecular medicine · 2017Review
- The UniProtKB guide to the human proteome.Database : the journal of biological databases and curation · 2016Article
- Inhibiting the inflammasome: one domain at a time.Immunological reviews · 2015Review
- An updated view on the structure and function of PYRIN domains.Apoptosis : an international journal on programmed cell death · 2015Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Pseudogenes are duplicated yet defunct copies of functional parent genes. However, some pseudogenes have gained or retained function. In this study, we consider a functional role for the NLRP2-related, higher primate-specific, processed pseudogene NLRP2P, which is closely related to Pyrin-only protein 2 (POP2/PYDC2), a regulator of nuclear factor-κB (NF-κB) and the inflammasome. The NLRP2P open-reading frame on chromosome X has features consistent with a processed pseudogene (retrotransposon), yet encodes a 45-amino-acid, Pyrin-domain-related protein. The open-reading frame of NLRP2P shares 80% identity with POP2 and is under purifying selection across Old World primates. Although widely expressed, NLRP2P messenger RNA is upregulated by lipopolysaccharide in human monocytic cells. Functionally, NLRP2P impairs NF-κB p65 transactivation by reducing activating phosphorylation of RelA/p65. Reminiscent of POP2, NLRP2P reduces production of the NF-κB-dependent cytokines tumor necrosis factor alpha and interleukin (IL)-6 following toll-like receptor stimulation. In contrast to POP2, NLRP2P fails to inhibit the ASC-dependent NLRP3 inflammasome. In addition, beyond regulating cytokine production, NLRP2P has a potential role in cell cycle regulation and cell death. Collectively, our findings suggest that NLRP2P is a resurrected processed pseudogene that regulates NF-κB RelA/p65 activity and thus represents the newest member of the POP family, POP4.
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