ArticleClinical and translational gastroenterology2014
Low Levels of 25-Hydroxy Vitamin D are Independently Associated with the Risk of Bacterial Infection in Cirrhotic Patients.
Article in Clinical and translational gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 64 citations in OpenAlex.
- The Modulatory Role of Vitamin D in the Molecular Mechanisms of Sepsis and Infections with Focus on Viral Pathogenesis: A Narrative Review.Pathogens (Basel, Switzerland) · 2026Review
- Treatment of Hypovitaminosis D Is Associated with Improvement in Anemia of Inflammation in Patients with Decompensated Cirrhosis.Medical sciences (Basel, Switzerland) · 2026Article
- Prognostic associations of vitamin D deficiency with disease severity, survival, and complications in alcohol-related liver disease.Frontiers in medicine · 2026Article
- Beyond bones: Revisiting the role of vitamin D in chronic liver disease.World journal of hepatology · 2025Review
- Vitamin D Supplementation Is Associated with Inflammation Amelioration and Cognitive Improvement in Decompensated Patients with Cirrhosis.Nutrients · 2025Article
- The Role of Vitamin D Deficiency in Hepatic Encephalopathy: A Review of Pathophysiology, Clinical Outcomes, and Therapeutic Potential.Nutrients · 2024Review
- Bacterial Infections in Acute-on-chronic Liver Failure: Epidemiology, Diagnosis, Pathogenesis, and Management.Journal of clinical and translational hepatology · 2024Review
- Role of Vitamin D in Liver Disease and Complications of Advanced Chronic Liver Disease.International journal of molecular sciences · 2022Review
- Vitamin D-VDR Novel Anti-Inflammatory Molecules-New Insights into Their Effects on Liver Diseases.International journal of molecular sciences · 2022Review
- Lack of association between B 12 and Body Mass Index among Saudi multiple sclerosis patients.Metabolism open · 2022Article
- Article
- Effect of vitamin D deficiency on spontaneous peritonitis in cirrhosis: a meta-analysis.Przeglad gastroenterologiczny · 2021Review
- Differential Impact of Serum 25-Hydroxyvitamin D3 Levels on the Prognosis of Patients with Liver Cirrhosis According to MELD and Child-Pugh Scores.Journal of Korean medical science · 2020Article
- Associated vitamin D deficiency is a risk factor for the complication of HCV-related liver cirrhosis including hepatic encephalopathy and spontaneous bacterial peritonitis.Internal and emergency medicine · 2019Observational
- Is vitamin D deficiency predictor of complications development in patients with HCV-related cirrhosis?Internal and emergency medicine · 2019Article
- Serum 25-hydroxyvitamin D levels and mortality risk in patients with liver cirrhosis: a protocol for a systematic review and meta-analysis of observational studies.Systematic reviews · 2019Article
- Effect of replenishment of vitamin D on survival in patients with decompensated liver cirrhosis: A prospective study.World journal of gastrointestinal pathophysiology · 2017Article
- Severe Vitamin D Deficiency Is Not Associated with Liver Damage in Morbidly Obese Patients.Obesity surgery · 2016Article
- Observational
- Vitamin D deficiency in chronic liver disease.World journal of hepatology · 2014Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesLow levels of vitamin D are associated with a higher mortality in cirrhotic patients, but the role of this deficiency is still unknown. The purpose of this study was to assess the levels of vitamin D in cirrhotic patients with and without bacterial infection.
methods25-hydroxy (25-OH) vitamin D was assessed by immunoassay in 88 patients hospitalized in our hepatology unit.
resultsThe causes of cirrhosis were mainly alcohol (70%), hepatitis C (10%), or both (9%). Infections (n=38) mainly included bacteriemia (21%), urinary tract infections (24%), and spontaneous bacterial peritonitis (29%). A severe deficiency in vitamin D (<10 ng/ml) was observed in 56.8% of patients. Infections were more frequent in patients with a severe deficiency compared with the others (54 vs. 29%, P=0.02). A severe deficiency in vitamin D was a predictive factor of infection (odds ratio=5.44 (1.35-21.97), P=0.017) independently of the Child-Pugh score (odds ratio=2.09 (1.47-2.97) P=0.00004) and the C-reactive protein level (odds ratio=1.03 (1.002-1.052), P=0.03) in a logistic regression also including the alanine amino transferase (not significant). By a Cox regression analysis, only the presence of an infection was significantly associated with mortality (relative risk=3.24 (1.20-8.76), P=0.02) in a model also associating the Child-Pugh score (not significant) and the presence of a severe deficiency in vitamin D (not significant).
conclusionsLow levels of 25-OH vitamin D were independently associated with bacterial infections in cirrhotic patients. The impact of 25-OH vitamin D supplementation on the infection rate and death of cirrhotic patients should be assessed in randomized trials.
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Registered trials
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