ArticlePloS one2014
Speech sound processing deficits and training-induced neural plasticity in rats with dyslexia gene knockdown.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Opposite Associations between Individual KIAA0319 Polymorphisms and Developmental Dyslexia Risk across Populations: A Stratified Meta-Analysis by the Study Population.Scientific reports · 2016Pooled it
- Use of a predictor cue during a speech sound discrimination task in a Cntnap2 knockout rat model of autism.PloS one · 2025Article
- Hyperexcitable and immature-like neuronal activity in the auditory cortex of adult rats lacking the language-linked CNTNAP2 gene.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Animal models of developmental dyslexia.Frontiers in neuroscience · 2022Review
- Identifying Dyslexia: Link between Maze Learning and Dyslexia Susceptibility Gene, DCDC2, in Young Children.Developmental neuroscience · 2021Article
- The dyslexia susceptibility KIAA0319 gene shows a specific expression pattern during zebrafish development supporting a role beyond neuronal migration.The Journal of comparative neurology · 2019Article
- Stable auditory processing underlies phonological awareness in typically developing preschoolers.Brain and language · 2019Article
- Increased variability of stimulus-driven cortical responses is associated with genetic variability in children with and without dyslexia.Developmental cognitive neuroscience · 2018Article
- Individual Differences in Reading Skill Are Related to Trial-by-Trial Neural Activation Variability in the Reading Network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Neurobiological Sex Differences in Developmental Dyslexia.Frontiers in psychology · 2018Article
- Shank3-deficient rats exhibit degraded cortical responses to sound.Autism research : official journal of the International Society for Autism Research · 2018Article
- Knockout Mice for Dyslexia Susceptibility Gene Homologs KIAA0319 and KIAA0319L have Unaffected Neuronal Migration but Display Abnormal Auditory Processing.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Individual Differences in Human Auditory Processing: Insights From Single-Trial Auditory Midbrain Activity in an Animal Model.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Neural stability: A reflection of automaticity in reading.Neuropsychologia · 2017Article
- Dyslexia risk gene relates to representation of sound in the auditory brainstem.Developmental cognitive neuroscience · 2017Article
- Normal radial migration and lamination are maintained in dyslexia-susceptibility candidate gene homolog Kiaa0319 knockout mice.Brain structure & function · 2017Article
- Lessons to be learned: how a comprehensive neurobiological framework of atypical reading development can inform educational practice.Current opinion in behavioral sciences · 2016Article
- Knockdown of Dyslexia-Gene Dcdc2 Interferes with Speech Sound Discrimination in Continuous Streams.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Overview of Transgenic Glioblastoma and Oligoastrocytoma CNS Models and Their Utility in Drug Discovery.Current protocols in pharmacology · 2016Review
- The regulatory element READ1 epistatically influences reading and language, with both deleterious and protective alleles.Journal of medical genetics · 2016Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
In utero RNAi of the dyslexia-associated gene Kiaa0319 in rats (KIA-) degrades cortical responses to speech sounds and increases trial-by-trial variability in onset latency. We tested the hypothesis that KIA- rats would be impaired at speech sound discrimination. KIA- rats needed twice as much training in quiet conditions to perform at control levels and remained impaired at several speech tasks. Focused training using truncated speech sounds was able to normalize speech discrimination in quiet and background noise conditions. Training also normalized trial-by-trial neural variability and temporal phase locking. Cortical activity from speech trained KIA- rats was sufficient to accurately discriminate between similar consonant sounds. These results provide the first direct evidence that assumed reduced expression of the dyslexia-associated gene KIAA0319 can cause phoneme processing impairments similar to those seen in dyslexia and that intensive behavioral therapy can eliminate these impairments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.