ArticleMolecular neurobiology2015
Anesthetic sevoflurane reduces levels of hippocalcin and postsynaptic density protein 95.
Article in Molecular neurobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 45 citations in OpenAlex.
- [Application of sevoflurane and laryngeal mask in cesarean section in women with heart disease].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2018Trial
- Multiple sevoflurane exposures in early development lead to long-term vascular abnormalities in the hippocampus.Cell biology and toxicology · 2026Article
- Sevoflurane induces CaCytotechnology · 2025Article
- GRIN2B alleviates mid-gestational sevoflurane exposure-induced early differentiation of rat neural stem cells by interacting with KIF17.Journal of cell communication and signaling · 2025Article
- Translatome and transcriptome profiling of neonatal mice hippocampus exposed to sevoflurane anesthesia.Heliyon · 2024Article
- Ac-YVAD-cmk ameliorated sevoflurane-induced cognitive dysfunction and revised mitophagy impairment.PloS one · 2023Article
- Sevoflurane-Induced Neurotoxicity in the Developing Hippocampus via HIPK2/AKT/mTOR Signaling.Neurotoxicity research · 2022Article
- Testosterone attenuates sevoflurane-induced tau phosphorylation and cognitive impairment in neonatal male mice.British journal of anaesthesia · 2021Article
- Brief inhalation of sevoflurane can reduce glial scar formation after hypoxic-ischemic brain injury in neonatal rats.Neural regeneration research · 2021Article
- Sevoflurane Promotes Neurodegeneration Through Inflammasome Formation in APP/PS1 Mice.Frontiers in neuroscience · 2021Article
- The differential effects of isoflurane and sevoflurane on neonatal mice.Scientific reports · 2020Article
- Effects of Sevoflurane Exposure During Late Pregnancy on Brain Development and Beneficial Effects of Enriched Environment on Offspring Cognition.Cellular and molecular neurobiology · 2020Article
- Interaction of Tau, IL-6 and mitochondria on synapse and cognition following sevoflurane anesthesia in young mice.Brain, behavior, & immunity - health · 2020Article
- Maternal sevoflurane exposure affects differentiation of hippocampal neural stem cells by regulating miR-410-3p and ATN1.Stem cell research & therapy · 2020Article
- Resveratrol Mitigates Sevoflurane-Induced Neurotoxicity by the SIRT1-Dependent Regulation of BDNF Expression in Developing Mice.Oxidative medicine and cellular longevity · 2020Article
- Sevoflurane plays a reduced role in cognitive impairment compared with isoflurane: limited effect on fear memory retention.Neural regeneration research · 2020Article
- Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice.Journal of neuroinflammation · 2019Article
- Disrupted folate metabolism with anesthesia leads to myelination deficits mediated by epigenetic regulation of ERMN.EBioMedicine · 2019Article
- Cyclophilin D Contributes to Anesthesia Neurotoxicity in the Developing Brain.Frontiers in cell and developmental biology · 2019Article
- Sevoflurane Impairs Short-Term Memory by Affecting PSD-95 and AMPA Receptor in the Hippocampus of a Mouse Model.Behavioural neurology · 2019Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Sevoflurane, the commonly used inhalation anesthetic in children, has been shown to enhance cytosolic calcium levels and induce cognitive impairment in young mice. However, the downstream consequences of the sevoflurane-induced elevation in cytosolic calcium levels and the upstream mechanisms of the sevoflurane-induced cognitive impairment remain largely to be determined. Hippocalcin is one of the neuronal calcium sensor proteins, and also binds to postsynaptic density protein 95 (PSD-95). We therefore set out to determine the effects of sevoflurane on the levels of hippocalcin and PSD-95 in vitro and in vivo. Hippocampus neurons from mice and 6-day-old mice were treated with 4.1% sevoflurane for 6 h or 3% sevoflurane 2 h daily for 3 days, respectively. We then measured the levels of hippocalcin and PSD-95, and assessed whether BAPTA, an intracellular calcium chelator, and memantine, a partial antagonist of the NMDA receptor, could inhibit the sevoflurane's effects. We found that sevoflurane decreased the levels of hippocalcin and PSD-95 in the neurons; and decreased the levels of hippocalcin and PSD-95 in the hippocampus of mice immediately after the anesthesia, but only the PSD-95 levels three weeks after the anesthesia. BAPTA inhibited the sevoflurane's effects in the neurons. Memantine attenuated the sevoflurane-induced reductions in the levels of hippocalcin and PSD-95, as well as the sevoflurane-induced cognitive impairment in mice. These data suggested that sevoflurane decreased the levels of hippocalcin and PSD-95, which could serve as one of bridge mechanisms between the sevoflurane-induced elevation of cytosolic calcium levels and the sevoflurane-induced cognitive impairment.
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