ArticleNature2014
A draft map of the human proteome.
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Article in Nature, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,144 papers, 1 of them a synthesis that pooled it.
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1,144citing papers in PubMed, 1 pooled it
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Who cites it
1,144 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- Improved Protein Identification in Shotgun Proteomics with a Group-Level Extension of the LPGF Model.Journal of proteome research · 2026Article
- Unbiased screen of human transcriptome reveals an unexpected role of 3'UTRs in translation initiation.Nature communications · 2026Article
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1,084 more citing papers are in PubMed but not listed here.
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Authors and funding
72 authors.
Min-Sik Kim1] McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [2] Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Sneha M PintoInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Derese Getnet1] McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [2] Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130, USA.
Raja Sekhar NirujogiInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Srikanth S MandaInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Raghothama Chaerkady1] McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [2] Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Anil K MadugunduInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Dhanashree S KelkarInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Ruth IsserlinThe Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada.
Shobhit JainThe Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada.
Joji K ThomasInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Babylakshmi MuthusamyInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Pamela Leal-Rojas1] McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [2] Department of Pathology, Universidad de La Frontera, Center of Genetic and Immunological Studies-Scientific and Technological Bioresource Nucleus, Temuco 4811230, Chile.
Praveen KumarInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Nandini A SahasrabuddheInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Lavanya BalakrishnanInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Jayshree AdvaniInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Bijesh GeorgeInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Santosh RenuseInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Lakshmi Dhevi N SelvanInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Arun H PatilInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Vishalakshi NanjappaInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Aneesha RadhakrishnanInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Samarjeet PrasadMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Tejaswini SubbannayyaInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Rajesh RajuInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Manish KumarInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Sreelakshmi K SreenivasamurthyInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Arivusudar MarimuthuInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Gajanan J SatheInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Sandip ChavanInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Keshava K DattaInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Yashwanth SubbannayyaInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Apeksha SahuInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Soujanya D YelamanchiInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Savita JayaramInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Pavithra RajagopalanInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Jyoti SharmaInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Krishna R MurthyInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Nazia SyedInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Renu GoelInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Aafaque A KhanInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Sartaj AhmadInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Gourav DeyInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Keshav MudgalSchool of Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
Aditi ChatterjeeInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Tai-Chung HuangMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Jun ZhongMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Xinyan Wu1] McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [2] Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Patrick G ShawMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Donald FreedMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Muhammad S ZahariDepartment of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Kanchan K MukherjeeDepartment of Neurosurgery, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India.
Subramanian ShankarDepartment of Internal Medicine Armed Forces Medical College, Pune 411040, India.
Anita Mahadevan1] Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore 560029, India [2] Human Brain Tissue Repository, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences, Bangalore 560029, India.
Henry LamDepartment of Chemical and Biomolecular Engineering and Division of Biomedical Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong.
Christopher J MitchellMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Susarla Krishna Shankar1] Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore 560029, India [2] Human Brain Tissue Repository, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences, Bangalore 560029, India.
Parthasarathy SatishchandraDepartment of Neurology, National Institute of Mental Health and Neurosciences, Bangalore 560029, India.
John T SchroederDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA.
Ravi SirdeshmukhInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Anirban Maitra1] The Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA [2] Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.
Steven D Leach1] McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [2] Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.
Charles G Drake1] Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA [2] Departments of Immunology and Urology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.
Marc K HalushkaThe Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.
T S Keshava PrasadInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Ralph H Hruban1] The Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA [2] Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.
Candace L Kerr1] Department of Obstetrics and Gynecology, Johns Hopkins University School of Medicine Baltimore, Maryland 21205, USA [2] Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
Gary D BaderThe Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada.
Christine A Iacobuzio-Donahue1] The Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA [2] Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA [3] Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.
Harsha GowdaInstitute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Akhilesh Pandey1] McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [2] Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [3] Institute of Bioinformatics, International Tech Park, Bangalore 560066, India [4] Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130, USA [5] The Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA [6] Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA [7] Diana Helis Henry Medical Research Foundation, New Orleans, Louisiana 70130, USA.
Funding
TR&D 3 - Network Guided Machine LearningP41GM103504 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IDEKER, TREY · 2012 to 2024
$17.3MProteome Characterization Center: A Genoproteomics Pipeline for Cance ResearchU24CA160036 · NCI · JOHNS HOPKINS UNIVERSITY · PI CHAN, DANIEL WANYUI, ZHANG, HUI · 2011 to 2016
$10.7MPredoctoral Training Program in Human GeneticsT32GM007814 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 1985 to 2021
$10.6MNetworks, Pathways and Dynamics of Lysine ModificationU54GM103520 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI BADER, JOEL S. · 2012 to 2013
$7.0MNCI NIH HHS U24 CA160036NCI NIH HHS U24CA160036NHLBI NIH HHS HHSN268201000032CNIGMS NIH HHS P41 GM103504NIGMS NIH HHS P41GM103504NIGMS NIH HHS T32 GM007814NIGMS NIH HHS U54 GM103520NIGMS NIH HHS U54GM103520
Abstract
The availability of human genome sequence has transformed biomedical research over the past decade. However, an equivalent map for the human proteome with direct measurements of proteins and peptides does not exist yet. Here we present a draft map of the human proteome using high-resolution Fourier-transform mass spectrometry. In-depth proteomic profiling of 30 histologically normal human samples, including 17 adult tissues, 7 fetal tissues and 6 purified primary haematopoietic cells, resulted in identification of proteins encoded by 17,294 genes accounting for approximately 84% of the total annotated protein-coding genes in humans. A unique and comprehensive strategy for proteogenomic analysis enabled us to discover a number of novel protein-coding regions, which includes translated pseudogenes, non-coding RNAs and upstream open reading frames. This large human proteome catalogue (available as an interactive web-based resource at http://www.humanproteomemap.org) will complement available human genome and transcriptome data to accelerate biomedical research in health and disease.
Indexed as
ProteomicsAdultCells, CulturedDatabases, ProteinFetusFourier AnalysisGene Expression ProfilingGenome, HumanHematopoietic Stem CellsHumansInternetMass SpectrometryMolecular Sequence AnnotationOpen Reading FramesOrgan SpecificityProtein BiosynthesisProtein IsoformsProtein Sorting SignalsProteomeRNA, UntranslatedUntranslated Regions
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