ArticleProceedings. Biological sciences2014
The effect of epistasis on sexually antagonistic genetic variation.
Article in Proceedings. Biological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Article
- A century of theories of balancing selection.Biological reviews of the Cambridge Philosophical Society · 2026Review
- The maintenance of genetic polymorphism underlying sexually antagonistic traits.Evolution letters · 2025Article
- Tests for associations between sexual dimorphism and patterns of quantitative genetic variation in the water strider, Aquarius remigis.Heredity · 2023Article
- X chromosomes show relaxed selection and complete somatic dosage compensation across Timema stick insect species.Journal of evolutionary biology · 2022Article
- A possible genomic footprint of polygenic adaptation on population divergence in seed beetles?Ecology and evolution · 2022Article
- Intrinsic emergence and modulation of sex-specific dominance reversals in threshold traits.Evolution; international journal of organic evolution · 2022Article
- Selection in males purges the mutation load on female fitness.Evolution letters · 2021Article
- A non-coding indel polymorphism in theProceedings. Biological sciences · 2021Article
- Genome-wide sexually antagonistic variants reveal long-standing constraints on sexual dimorphism in fruit flies.PLoS biology · 2019Article
- Dominance reversals and the maintenance of genetic variation for fitness.PLoS biology · 2019Article
- Sex-specific dominance reversal of genetic variation for fitness.PLoS biology · 2018Article
- Accumulation of Deleterious Mutations Near Sexually Antagonistic Genes.G3 (Bethesda, Md.) · 2016Article
- Sexually antagonistic selection on genetic variation underlying both male and female same-sex sexual behavior.BMC evolutionary biology · 2016Article
- A Paradox of Genetic Variance in Epigamic Traits: Beyond "Good Genes" View of Sexual Selection.Evolutionary biologyArticle
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3 authors.
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Abstract
There is increasing evidence of segregating sexually antagonistic (SA) genetic variation for fitness in laboratory and wild populations, yet the conditions for the maintenance of such variation can be restrictive. Epistatic interactions between genes can contribute to the maintenance of genetic variance in fitness and we suggest that epistasis between SA genes should be pervasive. Here, we explore its effect on SA genetic variation in fitness using a two locus model with negative epistasis. Our results demonstrate that epistasis often increases the parameter space showing polymorphism for SA loci. This is because selection in one locus is affected by allele frequencies at the other, which can act to balance net selection in males and females. Increased linkage between SA loci had more marginal effects. We also show that under some conditions, large portions of the parameter space evolve to a state where male benefit alleles are fixed at one locus and female benefit alleles at the other. This novel effect of epistasis on SA loci, which we term the 'equity effect', may have important effects on population differentiation and may contribute to speciation. More generally, these results support the suggestion that epistasis contributes to population divergence.
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