ArticlePloS one2014
Characterization of aging-associated cardiac diastolic dysfunction.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- [Heart failure with preserved ejection fraction in old age : Diagnostic strategies in clinical practice].Zeitschrift fur Gerontologie und Geriatrie · 2026Article
- Predictive Score for Significant Diastolic Dysfunction in Patients with Morbid Obesity Undergoing Bariatric Surgery.Journal of obesity & metabolic syndrome · 2025Article
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- Premature aging in genetic diseases: what conclusions can be drawn for physiological aging.Frontiers in aging · 2023Review
- Dysfunctional sarcomeric relaxation in the heart.Current opinion in physiology · 2022Article
- Development and validation of a nomogram for prediction of the risk of positive hidden blood loss in the perioperative period of single-level thoracolumbar burst fracture.Journal of orthopaedic surgery and research · 2021Article
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- Sirtuin 3, Endothelial Metabolic Reprogramming, and Heart Failure With Preserved Ejection Fraction.Journal of cardiovascular pharmacology · 2019Review
- Cardiac Abnormalities in Patients With Hutchinson-Gilford Progeria Syndrome.JAMA cardiology · 2018Observational
- Serum vitamin D, intact parathyroid hormone, and Fetuin A concentrations were associated with geriatric sarcopenia and cardiac hypertrophy.Scientific reports · 2017Article
- Interplay of Aging and Hypertension in Cardiac Remodeling: A Mathematical Geometric Model.PloS one · 2016Article
- Fetuin-A as a predicator of sarcopenic left ventricular dysfunction.Scientific reports · 2015Article
- Continuing treatment with Salvia miltiorrhiza injection attenuates myocardial fibrosis in chronic iron-overloaded mice.PloS one · 2015Article
- Prognostic value of ventricular diastolic dysfunction in patients with severe sepsis and septic shock.Revista Brasileira de terapia intensivaObservational
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsDiastolic dysfunction is common in geriatric heart failure. A reliable parameter to predict myocardium stiffness and relaxation under similar end-diastolic pressure is being developed. We propose a material and mathematical model for calculating myocardium stiffness based on the concept of linear correlation between [Formula: see text] and wedge pressure. METHODS AND
resultsWe enrolled 919 patients (male: [Formula: see text][Formula: see text]). Compared with the younger population of controls (mean age: [Formula: see text] years; [Formula: see text]; male: [Formula: see text] [Formula: see text]), the elderly (mean age: [Formula: see text]; [Formula: see text]; male: [Formula: see text] [Formula: see text]) had a greater prevalence of hypertension, diabetes mellitus, and coronary artery disease (all [Formula: see text]). We collected their M-mode and 2-D echocardiographic volumetric parameters, intraventricular filling pressure, and speckle tracking images to establish a mathematical model. The feasibility of this model was validated. The average early diastolic velocity of the mitral annulus assessed using tissue Doppler imaging was significantly attenuated in the elderly ([Formula: see text]: [Formula: see text] vs. [Formula: see text]; [Formula: see text]) and corresponded to the higher estimated wedge ([Formula: see text]) pressure ([Formula: see text] vs. [Formula: see text]; [Formula: see text]) in that cohort. E (Young's modulus) was calculated to describe the tensile elasticity of the myocardium. With the same intraventricular filling pressure, E was significantly higher in the elderly, especially those with [Formula: see text] values [Formula: see text]. Compared with diastolic dysfunction parameters, E also presented sentinel characteristics more sensitive for detecting early myocardial relaxation impairment, which indicates stiffer myocardium in aging hearts.
conclusionOur material and geometric mathematical model successfully described the stiffer myocardium in aging hearts with higher intraventricular pressure. Additional studies that compare individual differences, especially in health status, are needed to validate its application for detecting diastolic heart failure.
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