Evidence map›Paper›PMID 24869783›Full record

ArticleScientific reports2014

Exposure to 1800 MHz radiofrequency radiation impairs neurite outgrowth of embryonic neural stem cells.

Chunhai Chen, Qinlong Ma, Chuan Liu, Ping Deng, Gang Zhu, Lei Zhang, Mindi He, Yonghui Lu, Weixia Duan, Liping Pei and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
9.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 76 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Chunhai Chen1] Department of Occupational Health, Faculty of Preventive Medicine, Third Military Medical University, No.30 Gaotanyan Street, Chongqing 400038, China [2] Key Laboratory of Electromagnetic Radiation Protection, Third Military Medical University, No.30 Gaotanyan Street, Chongqing 400038, China.
Qinlong MaDepartment of Occupational Health, Faculty of Preventive Medicine, Third Military Medical University, No.30 Gaotanyan Street, Chongqing 400038, China.
Chuan LiuDepartment of Occupational Health, Faculty of Preventive Medicine, Third Military Medical University, No.30 Gaotanyan Street, Chongqing 400038, China.
Ping DengDepartment of Occupational Health, Faculty of Preventive Medicine, Third Military Medical University, No.30 Gaotanyan Street, Chongqing 400038, China.
Gang ZhuDepartment of Occupational Health, Faculty of Preventive Medicine, Third Military Medical University, No.30 Gaotanyan Street, Chongqing 400038, China.
Lei Zhang1] Department of Occupational Health, Faculty of Preventive Medicine, Third Military Medical University, No.30 Gaotanyan Street, Chongqing 400038, China [2] Key Laboratory of Electromagnetic Radiation Protection, Third Military Medical University, No.30 Gaotanyan Street, Chongqing 400038, China.
Mindi He1] Department of Occupational Health, Faculty of Preventive Medicine, Third Military Medical University, No.30 Gaotanyan Street, Chongqing 400038, China [2] Key Laboratory of Electromagnetic Radiation Protection, Third Military Medical University, No.30 Gaotanyan Street, Chongqing 400038, China.
Yonghui LuDepartment of Occupational Health, Faculty of Preventive Medicine, Third Military Medical University, No.30 Gaotanyan Street, Chongqing 400038, China.
Weixia DuanDepartment of Occupational Health, Faculty of Preventive Medicine, Third Military Medical University, No.30 Gaotanyan Street, Chongqing 400038, China.
Liping Pei1] Department of Occupational Health, Faculty of Preventive Medicine, Third Military Medical University, No.30 Gaotanyan Street, Chongqing 400038, China [2] Key Laboratory of Electromagnetic Radiation Protection, Third Military Medical University, No.30 Gaotanyan Street, Chongqing 400038, China.
Min LiDepartment of Occupational Health, Faculty of Preventive Medicine, Third Military Medical University, No.30 Gaotanyan Street, Chongqing 400038, China.
Zhengping Yu1] Department of Occupational Health, Faculty of Preventive Medicine, Third Military Medical University, No.30 Gaotanyan Street, Chongqing 400038, China [2] Key Laboratory of Electromagnetic Radiation Protection, Third Military Medical University, No.30 Gaotanyan Street, Chongqing 400038, China.
Zhou Zhou1] Department of Occupational Health, Faculty of Preventive Medicine, Third Military Medical University, No.30 Gaotanyan Street, Chongqing 400038, China [2] Key Laboratory of Electromagnetic Radiation Protection, Third Military Medical University, No.30 Gaotanyan Street, Chongqing 400038, China.
Army Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A radiofrequency electromagnetic field (RF-EMF) of 1800 MHz is widely used in mobile communications. However, the effects of RF-EMFs on cell biology are unclear. Embryonic neural stem cells (eNSCs) play a critical role in brain development. Thus, detecting the effects of RF-EMF on eNSCs is important for exploring the effects of RF-EMF on brain development. Here, we exposed eNSCs to 1800 MHz RF-EMF at specific absorption rate (SAR) values of 1, 2, and 4 W/kg for 1, 2, and 3 days. We found that 1800 MHz RF-EMF exposure did not influence eNSC apoptosis, proliferation, cell cycle or the mRNA expressions of related genes. RF-EMF exposure also did not alter the ratio of eNSC differentiated neurons and astrocytes. However, neurite outgrowth of eNSC differentiated neurons was inhibited after 4 W/kg RF-EMF exposure for 3 days. Additionally, the mRNA and protein expression of the proneural genes Ngn1 and NeuroD, which are crucial for neurite outgrowth, were decreased after RF-EMF exposure. The expression of their inhibitor Hes1 was upregulated by RF-EMF exposure. These results together suggested that 1800 MHz RF-EMF exposure impairs neurite outgrowth of eNSCs. More attention should be given to the potential adverse effects of RF-EMF exposure on brain development.

Indexed as

Electromagnetic FieldsAnimalsApoptosisCell PhoneCell ProliferationDose-Response Relationship, RadiationEmbryonic Stem CellsHumansMiceNeural Stem CellsNeuritesNeurogenesisRadio WavesRNA, MessengerRNA, Messenger

Identifiers

PMID24869783
PMCPMC4037711
OpenAlexW2091290017

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.