ReviewBone & joint research2014
Design and execution of clinical trials in orthopaedic surgery.
Review in Bone & joint research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- The Design of a Patient-Centered Hierarchal Composite Outcome for a Multi-Center Randomized Controlled Trial in Metastatic Bone Disease.Current oncology (Toronto, Ont.) · 2025Trial
- Acetabular cup fixation with and without screws following primary total hip arthroplasty: migration evaluated by radiostereometric analysis.Hip international : the journal of clinical and experimental research on hip pathology and therapy · 2024Trial
- Femoral stem migration after direct lateral and direct anterior total hip arthroplasty: a prospective cohort study.Canadian journal of surgery. Journal canadien de chirurgieTrial
- Biostatistical challenges in multicenter clinical trials: Best practices for collaboration and data harmonization across institutions.Bioinformation · 2025Article
- The 50 most cited studies on trochleoplasty.Journal of experimental orthopaedics · 2025Review
- Impact of Large Database Studies on Orthopedic Surgery Literature: Are We Advancing the Field?HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2023Article
- Propensity Scores: Confounder Adjustment When Comparing Nonrandomized Groups in Orthopaedic Surgery.The Journal of arthroplasty · 2023Review
- Fragility of statistically significant findings from randomized clinical trials of surgical treatment of humeral shaft fractures: A systematic review.World journal of orthopedics · 2022Article
- Assessment of Characteristics and Methodological Quality of the Top 50 Most Cited Articles on Platelet-Rich Plasma in Musculoskeletal Medicine.Orthopaedic journal of sports medicine · 2022Article
- The rise of registry-based research: a bibliometric analysis.Acta orthopaedica · 2021Review
- Assessment and Trends of the Methodological Quality of the Top 50 Most Cited Articles on Patellar Instability.Orthopaedic journal of sports medicine · 2021Article
- Assessment and Trends in the Methodological Quality of the Top 50 Most Cited Articles in Shoulder Instability.Orthopaedic journal of sports medicine · 2020Article
- Engineering Stem and Stromal Cell Therapies for Musculoskeletal Tissue Repair.Cell stem cell · 2018Review
- CORR InsightsClinical orthopaedics and related research · 2017Article
- Clinical research on postoperative trauma care: has the position of observational studies changed?European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2017Review
- Equipoise and the technology curve: Relevance in the design of Surgical trials.Bone & joint research · 2016Article
- [Distal radius fractures - Evidence is Shlevidence].Der Unfallchirurg · 2016Article
- The 50 Most Cited Articles in Orthopedic Cartilage Surgery.Cartilage · 2016Article
- Feasibility of individual patient data meta-analyses in orthopaedic surgery.BMC medicine · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-quality randomised controlled trials (RCTs) evaluating surgical therapies are fundamental to the delivery of evidence-based orthopaedics. Orthopaedic clinical trials have unique challenges; however, when these challenges are overcome, evidence from trials can be definitive in its impact on surgical practice. In this review, we highlight several issues that pose potential challenges to orthopaedic investigators aiming to perform surgical randomised controlled trials. We begin with a discussion on trial design issues, including the ethics of sham surgery, the importance of sample size, the need for patient-important outcomes, and overcoming expertise bias. We then explore features surrounding the execution of surgical randomised trials, including ethics review boards, the importance of organisational frameworks, and obtaining adequate funding. Cite this article: Bone Joint Res 2014;3:161-8.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.