ArticleJournal of diabetes research2014
Data mining for identifying novel associations and temporal relationships with Charcot foot.
Article in Journal of diabetes research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The trial behind it
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Who cites it
12 citing papers in PubMed.
- Vacuum Scaling Drainage in the Treatment of Infected Elbow Charcot Neuroarthropathy: A Case Report and Literature Review.The American journal of case reports · 2026Review
- Predictive Radiographic Values for Foot Ulceration in Persons with Charcot Foot Divided by Lateral or Medial Midfoot Deformity.Journal of clinical medicine · 2022Article
- Mapping the relationships between inflammatory bowel disease and comorbid diagnoses to identify disease associations.European journal of gastroenterology & hepatology · 2020Article
- Plantar fasciitis in patients with type 1 and type 2 diabetes: A contemporary cohort study.Journal of diabetes and its complications · 2019Article
- Markers of Local Inflammation and Bone Resorption in the Acute Diabetic Charcot Foot.Journal of diabetes research · 2018Article
- Article
- Pathogenesis and potential relative risk factors of diabetic neuropathic osteoarthropathy.Journal of orthopaedic surgery and research · 2017Review
- Large-scale Analysis of Opioid Poisoning Related Hospital Visits in New York State.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2017Article
- [Pathophysiology and etiology of the Charcot foot].Der Orthopade · 2015Article
- Charcot stage 0: A review and consideratons for making the correct diagnosis early.Clinical diabetes and endocrinology · 2015Review
- Precision medicine for managing diabetes.Journal of diabetes science and technology · 2015Article
- Charcot Neuropathic Arthropathy of the Foot: A Literature Review and Single-Center Experience.Journal of diabetes researchReview
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
INTRODUCTION. Charcot foot is a rare and devastating complication of diabetes. While some risk factors are known, debate continues regarding etiology. Elucidating other associated disorders and their temporal occurrence could lead to a better understanding of its pathogenesis. We applied a large data mining approach to Charcot foot for elucidating novel associations. METHODS. We conducted an association analysis using ICD-9 diagnosis codes for every patient in our health system (n = 1.6 million with 41.2 million time-stamped ICD-9 codes). For the current analysis, we focused on the 388 patients with Charcot foot (ICD-9 713.5). RESULTS. We found 710 associations, 676 (95.2%) of which had a P value for the association less than 1.0 × 10⁻⁵ and 603 (84.9%) of which had an odds ratio > 5.0. There were 111 (15.6%) associations with a significant temporal relationship (P < 1.0 × 10⁻³). The three novel associations with the strongest temporal component were cardiac dysrhythmia, pulmonary eosinophilia, and volume depletion disorder. CONCLUSION. We identified novel associations with Charcot foot in the context of pathogenesis models that include neurotrophic, neurovascular, and microtraumatic factors mediated through inflammatory cytokines. Future work should focus on confirmatory analyses. These novel areas of investigation could lead to prevention or earlier diagnosis.
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