Evidence map›Paper›PMID 24868525›Full record

ArticleBioMed research international2014

New insights into c-Ret signalling pathway in the enteric nervous system and its relationship with ALS.

M J Luesma, I Cantarero, J M Álvarez-Dotu, S Santander, C Junquera

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Thyroid C-Cell Biology and Oncogenic Transformation.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2025
    Review
  2. Article
  3. Article
  4. A review of the auditory-gut-brain axis.Frontiers in neuroscience · 2023
    Review
  5. Article
  6. A Gut Feeling in Amyotrophic Lateral Sclerosis: Microbiome of Mice and Men.Frontiers in cellular and infection microbiology · 2022
    Review
  7. Neurodegenerative disorders and gut-brain interactions.The Journal of clinical investigation · 2021
    Review
  8. Regulation of GDNF expression in Sertoli cells.Reproduction (Cambridge, England) · 2019
    Review
  9. Review
  10. Thyroid C-Cell Biology and Oncogenic Transformation.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

M J LuesmaDepartment of Human Anatomy and Histology, Faculty of Medicine, University of Zaragoza, Domingo Miral, s/n, 50009 Zaragoza, Spain ; Aragon Health Sciences Institute (I+CS), Zaragoza, Spain.
I CantareroDepartment of Cellular Biology, Physiology and Immunology, Faculty of Medicine, University of Córdoba, Spain ; Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Spain.
J M Álvarez-DotuDepartment of Obstetrics, Gynaecology and Surgery, University of Zaragoza, Spain.
S SantanderDepartment Pharmacology and Physiology, Faculty of Medicine, University of Zaragoza, Spain.
C JunqueraDepartment of Human Anatomy and Histology, Faculty of Medicine, University of Zaragoza, Domingo Miral, s/n, 50009 Zaragoza, Spain ; Aragon Health Sciences Institute (I+CS), Zaragoza, Spain.
Universidad de Zaragoza · ESInstituto de Investigación Sanitaria Aragón · ESInstituto Maimónides de Investigación Biomédica de Córdoba · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The receptor tyrosine kinase Ret (c-Ret) transduces the glial cell line-derived neurotrophic factor (GDNF) signal, one of the neurotrophic factors related to the degeneration process or the regeneration activity of motor neurons in amyotrophic lateral sclerosis (ALS). The phosphorylation of several tyrosine residues of c-Ret seems to be altered in ALS. c-Ret is expressed in motor neurons and in the enteric nervous system (ENS) during the embryonic period. The characteristics of the ENS allow using it as model for central nervous system (CNS) study and being potentially useful for the research of human neurological diseases such as ALS. The aim of the present study was to investigate the cellular localization and quantitative evaluation of marker c-Ret in the adult human gut. To assess the nature of c-Ret positive cells, we performed colocalization with specific markers of cells that typically are located in the enteric ganglia. The colocalization of PGP9.5 and c-Ret was preferentially intense in enteric neurons with oval morphology and mostly peripherally localized in the ganglion, so we concluded that the c-Ret receptor is expressed by a specific subtype of enteric neurons in the mature human ENS of the gut. The functional significance of these c-Ret positive neurons is discussed.

Indexed as

Signal TransductionAdultAgedAmyotrophic Lateral SclerosisEnteric Nervous SystemGangliaGlial Fibrillary Acidic ProteinHumansImmunohistochemistryMicroscopy, FluorescenceMiddle AgedNeuronsPhosphorylationProto-Oncogene Proteins c-kitProto-Oncogene Proteins c-retUbiquitin ThiolesteraseGlial Fibrillary Acidic ProteinProto-Oncogene Proteins c-kitProto-Oncogene Proteins c-retUbiquitin ThiolesteraseUCHL1 protein, human

Identifiers

PMID24868525
PMCPMC4020535
OpenAlexW2005385479

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.