ArticleOxidative medicine and cellular longevity2014
Leucocyte telomere shortening in relation to newly diagnosed type 2 diabetic patients with depression.
Article in Oxidative medicine and cellular longevity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 4 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 4 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Exploring the association between depression and telomere length: A systematic review and meta-analysis.Scientific reports · 2025Pooled it
- Pooled it
- Association between telomere length and diabetes mellitus: A meta-analysis.The Journal of international medical research · 2016Pooled it
- Depression and telomere length: A meta-analysis.Journal of affective disorders · 2016Pooled it
- The Association of Ramadan Fasting on Relative Leukocyte Telomere Length in Type 2 Diabetes Mellitus.Journal of the ASEAN Federation of Endocrine Societies · 2026Article
- Early emergence of sexual dimorphism in offspring leukocyte telomere length was associated with maternal and children's glucose metabolism-a longitudinal study.BMC medicine · 2022Article
- Telomere length and telomere repeat-binding protein in children with sickle cell disease.Pediatric research · 2022Article
- Association of antidiabetic therapy with shortened telomere length in middle-aged Type 2 diabetic patients.Journal of diabetes and metabolic disorders · 2021Article
- Genetic, Environmental and Lifestyle Determinants of Accelerated Telomere Attrition as Contributors to Risk and Severity of Multiple Sclerosis.Biomolecules · 2021Review
- 8-Hydroxy-2'-Deoxyguanosine and Reactive Oxygen Species as Biomarkers of Oxidative Stress in Mental Illnesses: A Meta-Analysis.Psychiatry investigation · 2021Article
- Functional interaction between plasma phospholipid fatty acids and insulin resistance in leucocyte telomere length maintenance.Lipids in health and disease · 2020Article
- The relation of telomere length at midlife to subsequent 20-year depression trajectories among women.Depression and anxiety · 2019Article
- Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging.Neuroscience and biobehavioral reviews · 2015Review
- Telomeres, early-life stress and mental illness.Advances in psychosomatic medicine · 2015Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The goal of this study is to investigate the association between oxidative stress and telomere length shortening in the comorbid depression and diabetes. Therefore, 71 patients with newly diagnosed type 2 diabetes (T2D) and 52 subjects with normal glycemic level (control, Ctrl) were enrolled. Depressive status was identified with the Depression Subscale of Hospital Anxiety and Depression Scale (HADS-D). Leukocyte telomere length ratio (T/S ratio) was determined with quantitative PCR. Oxidative stress status was evaluated with 8-hydroxy-desoxyguanosine (8-OHdG) assay kit. Some other biochemical blood testing was also performed. The data showed that T2D patients had higher proportion of depression evaluated by the HADS-D (x(2) = 4.196, P = 0.041). T/S ratio was significantly negatively correlated with 8-OHdG, HADS-D, age, HbA1c, FPG, and HOMA-IR. In addition, HADS-D was significantly positively correlated with HbA1c, FPG, HOMA-IR, and 8-OHdG. Both HADS-D and 8-OHdG were the major independent predictors for T/S ratio. This study indicates that oxidative stress contributes to both telomere length shortening and depression development in newly diagnosed type 2 diabetic patients, while in depression status, some other mechanisms besides oxidative stress may also affect the telomere length.
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