ArticlePrzeglad gastroenterologiczny2014
Functional dyspepsia symptom resolution after Helicobacter pylori eradication with two different regimens.
Article in Przeglad gastroenterologiczny, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Efficacies of different proton pump inhibitor-based 14-day bismuth-furazolidone quadruple regimens for the initial eradication of Helicobacter pylori in the southeast coastal region of China: an open-label, randomized clinical trial.Clinical and experimental medicine · 2018Trial
- Trial
- Relationship between Helicobacter pylori and idiopathic chronic urticaria: effectiveness of Helicobacter pylori eradication.Postepy dermatologii i alergologii · 2015Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionFunctional dyspepsia (FD), a common functional gastrointestinal disorder, has a complex underlying pathophysiological mechanism that involves changes in gastric motility, visceral hypersensitivity, genetic susceptibility, psychosocial factors and Helicobacter pylori infection. Although there are several H. pylori eradication treatments, there is not enough data that compare these different eradication treatments for FD symptom resolution. Most previous studies have focused on the eradication rates of H. pylori rather than symptom relief in FD.
aimIn this regard, we aimed to clarify if there is any difference between standard triple therapy and sequential therapy for symptom resolution of FD patients with H. pylori, using a validated health quality index. MATERIAL AND
methodsA total of 194 patients were included in this study. The patients were randomly assigned to receive standard triple therapy (omeprazole, amoxicilline and clarithromycin for 14 days) or sequential therapy (omeprazole plus amoxicilline for 7 days and omeprazole twice daily, metronidazole and clarithromycin for a subsequent 7 days) by a blind physician for H. pylori status. Outcome measures were based on symptomatic improvement at 12 months using a validated measure of subjective well-being (Gastrointestinal Symptom Rating Scale - GSRS).
resultsWe observed significant symptom resolution at 12 months in both treatment groups. On the other hand, there was no difference between the sequential or standard triple therapy groups regarding the alleviation of symptoms.
conclusionsNo difference for symptom relief exists between sequential and triple therapy in patients with FD.
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