Evidence map›Paper›PMID 24868122›Full record

ArticleBehavioural neurology2014

Preclinical polymodal hallucinations for 13 years before dementia with Lewy bodies.

Carlo Abbate, Pietro Davide Trimarchi, Silvia Inglese, Niccolò Viti, Alessandra Cantatore, Lisa De Agostini, Federico Pirri, Lorenza Marino, Renzo Bagarolo, Daniela Mari

Open access · goldAbstract readCase Reports
In one paragraph

Article in Behavioural neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Carlo AbbateFondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Unità Operativa Complessa di Geriatria, Via Pace 9, 20122 Milan, Italy.
Pietro Davide TrimarchiFondazione IRCCS Don Carlo Gnocchi, ONLUS, S. Maria Nascente, Via Capecelatro 66, 20148 Milan, Italy.
Silvia IngleseFondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Unità Operativa Complessa di Geriatria, Via Pace 9, 20122 Milan, Italy.
Niccolò VitiFondazione IRCCS Don Carlo Gnocchi, ONLUS, S. Maria Nascente, Via Capecelatro 66, 20148 Milan, Italy.
Alessandra CantatoreFondazione IRCCS Don Carlo Gnocchi, ONLUS, S. Maria Nascente, Via Capecelatro 66, 20148 Milan, Italy.
Lisa De AgostiniFondazione IRCCS Don Carlo Gnocchi, ONLUS, S. Maria Nascente, Via Capecelatro 66, 20148 Milan, Italy.
Federico PirriFondazione IRCCS Don Carlo Gnocchi, ONLUS, S. Maria Nascente, Via Capecelatro 66, 20148 Milan, Italy.
Lorenza MarinoFondazione IRCCS Don Carlo Gnocchi, ONLUS, S. Maria Nascente, Via Capecelatro 66, 20148 Milan, Italy.
Renzo BagaroloFondazione IRCCS Don Carlo Gnocchi, ONLUS, S. Maria Nascente, Via Capecelatro 66, 20148 Milan, Italy.
Daniela MariFondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Unità Operativa Complessa di Geriatria, Via Pace 9, 20122 Milan, Italy ; Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano, Via Della Commenda 9/12, 20122 Milan, Italy.ORCID 0000-0002-6950-0789
Don Carlo Gnocchi Foundation · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe describe a case of dementia with Lewy bodies (DLB) that presented long-lasting preclinical complex polymodal hallucinations.

backgroundFew studies have deeply investigated the characteristics of hallucinations in DLB, especially in the preclinical phase. Moreover, the clinical phenotype of mild cognitive impairment-(MCI-) DLB is poorly understood.

methodsThe patient was followed for 4 years and a selective phenomenological and cognitive study was performed at the predementia stage.

resultsThe phenomenological study showed the presence of hypnagogic and hypnopompic hallucinations that allowed us to make a differential diagnosis between DLB and Charles Bonnet syndrome (CBS). The neuropsychological evaluation showed a multiple domain without amnesia MCI subtype with prefrontal dysexecutive, visuoperceptual, and visuospatial impairments and simultanagnosia, which has not previously been reported in MCI-DLB.

conclusionsThis study extends the prognostic value of hallucinations for DLB to the preclinical phases. It supports and refines the MCI-DLB concept and identifies simultanagnosia as a possible early cognitive marker. Finally, it confirms an association between hallucinations and visuoperceptual impairments at an intermediate stage of the disease course and strongly supports the hypothesis that hallucinations in the earliest stages of DLB may reflect a narcolepsy-like REM-sleep disorder.

Indexed as

Prodromal SymptomsAged, 80 and overDisease ProgressionFemaleHallucinationsHumansLewy Body DiseaseNeuropsychological Tests

Identifiers

PMID24868122
PMCPMC4020531
OpenAlexW2010412840

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.