ArticleDisease markers2014
Haptoglobin 2-2 genotype is associated with TNF- α and IL-6 levels in subjects with obesity.
Article in Disease markers, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Upregulation of the Intestinal Paracellular Pathway with Breakdown of Tight and Adherens Junctions in Deficit Schizophrenia.Molecular neurobiology · 2019Article
- Unique Contribution of Haptoglobin and Haptoglobin Genotype in Aneurysmal Subarachnoid Hemorrhage.Frontiers in physiology · 2018Review
- Does the Concentration of Oxidative and Inflammatory Biomarkers Differ by Haptoglobin Genotype in Type 1 Diabetes?Antioxidants & redox signaling · 2015Article
- Haptoglobin gene polymorphisms and interleukin-6 and -8 levels in patients with sickle cell anemia.Revista brasileira de hematologia e hemoterapiaArticle
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the association between Haptoglobin (HP) gene polymorphisms with inflammatory status in obese subjects. MATERIALS AND
methodsA cross-sectional study was carried out. A total of 276 apparently healthy men and nonpregnant obese women were enrolled and allocated according to the HP genotype into the HP (1)/HP (1), HP (2)/HP (1), and HP (2)/HP (2) groups. Distribution of HP genotypes was 49, 87, and 140 for the HP (1)/HP (1), HP (2)/HP (1), and HP (2)/HP (2), respectively. The HP genotype was determined using the polymerase chain reaction method. A multiple linear regression analysis adjusted by age, sex, waist circumference, and total body fat was used to determine the association between HP genotypes with TNF- α , IL-6, and high-sensitivity C-reactive protein (hsCRP) levels.
resultsA multiple linear regression analysis adjusted by sex, waist circumference, and total body fat was performed showing a significant association between the HP (2)/HP (2) genotype and TNF- α ( β = 0.180; 95% CI 14.41-159.64, P = 0.01) and IL-6 ( β = 0.188; 95% CI 1.53-12.72, P = 0.01) levels, but not with hsCRP ( β = -0.008; 95% CI -1.64-1.47, P = 0.914) levels, whereas the HP (2)/HP (1) genotype showed no association compared with the HP (1)/HP (1) genotype (control group).
conclusionResults of our study show that the HP (2)/HP (2) genotype is associated with elevated TNF- α and IL-6, but not with hsCRP, levels in obese subjects.
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