Evidence map›Paper›PMID 24867974›Full record

ArticleAntimicrobial agents and chemotherapy2014

Decreased ceftriaxone susceptibility in emerging (35B and 6C) and persisting (19A) Streptococcus pneumoniae serotypes in the United States, 2011-2012: ceftaroline remains active in vitro among β-lactam agents.

Rodrigo E Mendes, Donald Biek, Ian A Critchley, David J Farrell, Helio S Sader, Ronald N Jones

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Antimicrobial Susceptibility ofOpen forum infectious diseases · 2019
    Article
  2. Antimicrobial agents and chemotherapy · 2018
    Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rodrigo E MendesJMI Laboratories, North Liberty, Iowa, USA rodrigo-mendes@jmilabs.com.
Donald BiekCerexa, Inc., Oakland, California, USA.
Ian A CritchleyCerexa, Inc., Oakland, California, USA.
David J FarrellJMI Laboratories, North Liberty, Iowa, USA.
Helio S SaderJMI Laboratories, North Liberty, Iowa, USA.
Ronald N JonesJMI Laboratories, North Liberty, Iowa, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Totals of 8.7% (103/1,190) and 21.0% (249/1,190) of the Streptococcus pneumoniae isolates recovered from specimens collected in the United States during the 2011-2012 AWARE (Assessing Worldwide Antimicrobial Resistance Evaluation) Surveillance Program were ceftriaxone nonsusceptible according to the CLSI (≤ 1 μg/ml for susceptible) and EUCAST (≤ 0.5 μg/ml for susceptible) criteria, respectively. Decreased susceptibility to ceftriaxone (MIC, 1 μg/ml) was frequently observed among serotypes 19 A (51.4%; 128/249) and 35 B (29.7%; 74/249), which were most often observed in the East South Central and South Atlantic U.S. Census regions. Ceftaroline (MIC50/90, 0.12/0.25 μg/ml) remained active (≥ 96.8% susceptible) when tested against these less susceptible isolates.

Indexed as

beta-Lactam ResistanceAnti-Bacterial AgentsCeftarolineCeftriaxoneCephalosporinsHumansMicrobial Sensitivity TestsMolecular EpidemiologyPneumococcal InfectionsSerogroupSerotypingStreptococcus pneumoniaeUnited StatesAnti-Bacterial AgentsCeftarolineCeftriaxoneCephalosporins

Identifiers

PMID24867974
PMCPMC4136078

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.