Evidence map›Paper›PMID 24867959›Full record

Trial reportIntegrative cancer therapies2014

A pilot study of acupuncture in treating bortezomib-induced peripheral neuropathy in patients with multiple myeloma.

Ting Bao, Olga Goloubeva, Colleen Pelser, Neil Porter, James Primrose, Lisa Hester, Mariola Sadowska, Rena Lapidus, Michelle Medeiros, Lixing Lao and 2 more

2 registry-linked trialsAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Integrative cancer therapies, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 35 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02831114 nacompletednot on this mapstarted 2016, after this paper: background citation

Evaluating the Effects of Acupuncture in the Treatment of Taxane Induces Peripheral Neuropathy (TIPN)

TypeinterventionalSponsorPrisma Health-UpstateRan2016 to 2018Enrolled18ConditionsPeripheral NeuropathyArmsAcupuncture
NCT04144309 nacompletednot on this mapstarted 2019, after this paper: background citation

The Effect of Acupuncture for Insomnia in Breast Cancer Patients Undergoing Chemotherapy: A Randomized, Sham-Controlled Trial

TypeinterventionalSponsorThe University of Hong KongRan2019 to 2022Enrolled138ConditionsInsomnia, Secondary, Breast Cancer Female, ChemotherapyArmsElectroacupuncture (EA) and Auricular Acupressure (AA), Sham Electroacupuncture (SE) and Sham Auricular Acupressure (SA)
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ting BaoThe University of Maryland School of Medicine, Baltimore, MD, USA baot@mskcc.org.
Olga GoloubevaThe University of Maryland School of Medicine, Baltimore, MD, USA.
Colleen PelserThe University of Maryland School of Medicine, Baltimore, MD, USA.
Neil PorterThe University of Maryland School of Medicine, Baltimore, MD, USA.
James PrimroseThe University of Maryland School of Medicine, Baltimore, MD, USA.
Lisa HesterThe University of Maryland School of Medicine, Baltimore, MD, USA.
Mariola SadowskaThe University of Maryland School of Medicine, Baltimore, MD, USA.
Rena LapidusThe University of Maryland School of Medicine, Baltimore, MD, USA.
Michelle MedeirosThe University of Maryland School of Medicine, Baltimore, MD, USA.
Lixing LaoThe University of Maryland School of Medicine, Baltimore, MD, USA.
Susan G DorseyThe University of Maryland School of Medicine, Baltimore, MD, USA.
Ashraf Z BadrosThe University of Maryland School of Medicine, Baltimore, MD, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
UMGCC Paul Calabresi Clinical Oncology Training ProgramK12CA126849 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI SAUSVILLE, EDWARD A. · 2008 to 2013
$4.0M
UMB Center for Pain StudiesP30NR011396 · NINR · UNIVERSITY OF MARYLAND BALTIMORE · PI DORSEY, SUSAN G · 2009 to 2013
$3.6M
Acupuncture to Prevent Chemotherapy Dose ReductionR21CA173263 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI BAO, TING · 2013 to 2014
$349k
NCI NIH HHS K12 CA126849NCI NIH HHS P30 CA008748NCI NIH HHS R21 CA173263NINR NIH HHS P30 NR011396NINR NIH HHS P30NR011396
6 · The paper itself

Abstract

backgroundPeripheral neuropathy is the dose limiting toxicity of bortezomib in patients with multiple myeloma (MM).

objectivesTo examine the safety, feasibility and efficacy of acupuncture in reducing bortezomib-induced peripheral neuropathy (BIPN) symptoms.

methodsPatients with MM experiencing persistent BIPN ≥grade 2 despite adequate medical intervention and discontinuation of bortezomib received 10 acupuncture treatments for 10 weeks (2×/week for 2 weeks, 1×/week for 4 weeks, and then biweekly for 4 weeks). Responses were assessed by the Clinical Total Neuropathy Score (TNSc), Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOG-Ntx) questionnaire, and the Neuropathy Pain Scale (NPS). Repeated-measures analysis of variance was used to test for monotonic decline in scores on each of the measures. Serial serum levels of proinflammatory and neurotrophic cytokines were obtained at baseline and weeks 1, 2, 4, 8, and 14.

resultsTwenty-seven patients with MM were enrolled in the trial. There were no adverse events associated with the acupuncture treatments. TNSc data were deemed invalid and therefore were not reported. At weeks 10 and 14, FACT/GOG-Ntx and NPS showed significant reduction suggesting decreased pain, and improved function (P values were <.0001 for both FACT/GOG-Ntx and NPS at weeks 10 and 14). However, nerve conduction studies did not significantly change between baseline assessment and end of study. There was no correlation in serum cytokines for responders versus none responders.

conclusionsAcupuncture is safe, feasible and produces subjective improvements in patients' symptoms. A follow-up randomized controlled trial is warranted.

Indexed as

Acupuncture TherapyAgedAntineoplastic AgentsBoronic AcidsBortezomibCytokinesFeasibility StudiesHumansMiddle AgedMultiple MyelomaPain MeasurementPeripheral Nervous System DiseasesPilot ProjectsPyrazinesTime FactorsTreatment OutcomeAntineoplastic AgentsBoronic AcidsBortezomibCytokinesPyrazinesacupuncturebortezomibmultiple myelomaperipheral neuropathy

Identifiers

PMID24867959
PMCPMC4562796

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.