Evidence map›Paper›PMID 24867789›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2014

Etiology of severe childhood pneumonia in the Gambia, West Africa, determined by conventional and molecular microbiological analyses of lung and pleural aspirate samples.

Stephen R C Howie, Gerard A J Morris, Rafal Tokarz, Bernard E Ebruke, Eunice M Machuka, Readon C Ideh, Osaretin Chimah, Ousman Secka, John Townend, Michel Dione and 11 more

Abstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Pooled it
  4. Pooled it
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  6. Article
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  8. Human bocavirus-1 infections in Australian children aged < 2 years: a birth cohort study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2023
    Article
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  12. Observational
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  15. The Etiology of Pneumonia From Analysis of Lung Aspirate and Pleural Fluid Samples: Findings From the Pneumonia Etiology Research for Child Health (PERCH) Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Stephen R C HowieMedical Research Council Unit, Fajara, Republic of The Gambia.
Gerard A J MorrisMedical Research Council Unit, Fajara, Republic of The Gambia.
Rafal TokarzCenter for Infection and Immunity, Columbia University, New York, New York.
Bernard E EbrukeMedical Research Council Unit, Fajara, Republic of The Gambia.
Eunice M MachukaMedical Research Council Unit, Fajara, Republic of The Gambia.
Readon C IdehMedical Research Council Unit, Fajara, Republic of The Gambia.
Osaretin ChimahMedical Research Council Unit, Fajara, Republic of The Gambia.
Ousman SeckaMedical Research Council Unit, Fajara, Republic of The Gambia.
John TownendMedical Research Council Unit, Fajara, Republic of The Gambia.
Michel DioneMedical Research Council Unit, Fajara, Republic of The Gambia.
Claire OluwalanaMedical Research Council Unit, Fajara, Republic of The Gambia.
Malick NjieMinistry of Health and Social Welfare, Banjul, Republic of The Gambia.
Mariatou JallowMinistry of Health and Social Welfare, Banjul, Republic of The Gambia.
Philip C HillCentre for International Health, University of Otago, Dunedin, New Zealand.
Martin AntonioMedical Research Council Unit, Fajara, Republic of The Gambia.
Brian GreenwoodLondon School of Hygiene and Tropical Medicine, United Kingdom.
Thomas BrieseCenter for Infection and Immunity, Columbia University, New York, New York.
Kim MulhollandLondon School of Hygiene and Tropical Medicine, United Kingdom.
Tumani CorrahMedical Research Council Unit, Fajara, Republic of The Gambia.
W Ian LipkinCenter for Infection and Immunity, Columbia University, New York, New York.
Richard A AdegbolaMedical Research Council Unit, Fajara, Republic of The Gambia GlaxoSmithKline Vaccines, Wavre, Belgium.

Funding

Medical Research Council MC_U190088478Medical Research Council MC_UP_A900_1124
6 · The paper itself

Abstract

Molecular analyses of lung aspirates from Gambian children with severe pneumonia detected pathogens more frequently than did culture and showed a predominance of bacteria, principally Streptococcus pneumoniae, >75% being of serotypes covered by current pneumococcal conjugate vaccines. Multiple pathogens were detected frequently, notably Haemophilus influenzae (mostly nontypeable) together with S. pneumoniae.

Indexed as

Africa, WesternBacterial ProteinsCarrier ProteinsChild, PreschoolCoinfectionGambiaHaemophilus InfectionsHaemophilus influenzaeHumansImmunoglobulin DInfantLipoproteinsLungMultilocus Sequence TypingPneumococcal VaccinesPneumonia, BacterialBacterial ProteinsCarrier ProteinsCpsA protein, Streptococcus pneumoniaeglpQ protein, Haemophilus influenzaeImmunoglobulin DLipoproteinsPneumococcal VaccineschildrenetiologyGambialung aspiratepneumonia

Identifiers

PMID24867789
PMCPMC4130311

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.