Trial reportBritish journal of cancer2014
Safety and efficacy of resistance training in germ cell cancer patients undergoing chemotherapy: a randomized controlled trial.
Trial report in British journal of cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 21 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Quantitative Fluorescent Guided Robotic Surgery for Cancer of the Gastroesophageal Junction
The Effect of Chemoradiotherapy on Gastric Perfusion in Patients With Gastric Cancer.
Who cites it
21 citing papers in PubMed, 8 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Effects of different exercise prescription parameters on metabolic and inflammatory biomarkers in cancer patients: a systematic review, meta-analysis, and meta-regression.Frontiers in immunology · 2025Pooled it
- Effects of resistance training on quality of life, fatigue, physical function, and muscular strength during chemotherapy treatment: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Pooled it
- Dose-response relationship of resistance training for muscle morphology and strength in elderly cancer patients: A meta-analysis.Frontiers in medicine · 2023Pooled it
- Efficacy of resistance training during adjuvant chemotherapy and radiation therapy in cancer care: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Pooled it
- The Effect of Resistance Training on Body Composition During and After Cancer Treatment: A Systematic Review and Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2021Pooled it
- Attention to principles of exercise training: an updated systematic review of randomized controlled trials in cancers other than breast and prostate.BMC cancer · 2021Pooled it
- Interventions for promoting habitual exercise in people living with and beyond cancer.The Cochrane database of systematic reviews · 2018Pooled it
- The Independent Effects of Strength Training in Cancer Survivors: a Systematic Review.Current oncology reports · 2016Pooled it
- Effect of exercise on body composition among women with ovarian cancer.Journal of cancer survivorship : research and practice · 2023Trial
- Feasibility of a physical activity intervention during and shortly after chemotherapy for testicular cancer.BMC research notes · 2017Trial
- Trial
- Resistance Exercise Counteracts the Impact of Androgen Deprivation Therapy on Muscle Characteristics in Cancer Patients.The Journal of clinical endocrinology and metabolism · 2023Article
- Harms of exercise training in patients with cancer undergoing systemic treatment: a systematic review and meta-analysis of published and unpublished controlled trials.EClinicalMedicine · 2023Article
- Effects of exercise on AKT/PGC1-α/FOXO3a pathway and muscle atrophy in cisplatin-administered rat skeletal muscle.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2021Article
- Effects of Exercise on the Tumour Microenvironment.Advances in experimental medicine and biology · 2020Review
- Electrical stimulation prevents doxorubicin-induced atrophy and mitochondrial loss in cultured myotubes.American journal of physiology. Cell physiology · 2019Article
- Clinical and biological characterization of skeletal muscle tissue biopsies of surgical cancer patients.Journal of cachexia, sarcopenia and muscle · 2019Article
- Anaesthesia for retroperitoneal lymph node dissection in the treatment of testicular cancer.BJA education · 2019Review
- Treatment-related cardiovascular late effects and exercise training countermeasures in testicular germ cell cancer survivorship.Acta oncologica (Stockholm, Sweden) · 2015Review
- Muscle wasting in cancer: opportunities and challenges for exercise in clinical cancer trials.JCSM rapid communicationsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBleomycin-etoposid-cisplatin (BEP) chemotherapy is curative in most patients with disseminated germ cell cancer (GCC) but also associated with toxic actions and dysfunction in non-targeted tissues. We investigated changes in muscle function during BEP and the safety and efficacy of resistance training to modulate these changes.
methodsThirty GCC patients were randomly assigned to resistance training (resistance training group (INT), n=15) or usual care (CON, n=15) during 9 weeks of BEP therapy. Resistance training consisted of thrice weekly sessions of four exercises, 3-4 sets/exercise of 10-15 repetitions at 12-15 repetition maximum load. The primary endpoint was muscle fibre size, assessed in muscle biopsies from musculus vastus lateralis. Secondary endpoints were fibre phenotype composition, body composition, strength, blood biochemistry and patient-reported endpoints. Healthy age-matched subjects (REF, n=19) performed the same RT-programme for comparison purposes.
resultsMuscle fibre size decreased by -322 μm(2) (95% confidence interval (CI): -899 to 255; P=0.473) in the CON-group and increased by +206 μm(2) (95% CI: -384 to 796; P=0.257) in the INT-group (adjusted mean difference (AMD), +625 μm(2), 95% CI: -253 to 1503, P=0.149). Mean differences in type II fibre size (AMD, +823 μm(2), P=0.09) and lean mass (AMD, +1.49 kg, P=0.07) in favour of the INT-group approached significance. The REF-group improved all muscular endpoints and had significantly superior changes compared with the INT-group (P<0.05).
conclusionsBEP was associated with significant reduction in lean mass and strength and trends toward unfavourable changes in muscle fibre size and phenotype composition. Resistance training was safe and attenuated dysfunction in selected endpoints, but BEP blunted several positive adaptations observed in healthy controls. Thus, our study does not support the general application of resistance training in this setting but larger-scaled trials are required to confirm this finding.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.