ReviewCurrent opinion in nephrology and hypertension2014
New functional aspects of the extracellular calcium-sensing receptor.
Review in Current opinion in nephrology and hypertension, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Association study ofOpen life sciences · 2022Article
- Tryptophan Ameliorates Barrier Integrity and Alleviates the Inflammatory Response to EnterotoxigenicFrontiers in immunology · 2021Article
- Factors inhibiting intestinal calcium absorption: hormones and luminal factors that prevent excessive calcium uptake.The journal of physiological sciences : JPS · 2019Review
- The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases.Nature reviews. Endocrinology · 2018Review
- Treatment of extreme hypercalcaemia: the role of haemodialysis.BMJ case reports · 2018Article
- Interrelated role of Klotho and calcium-sensing receptor in parathyroid hormone synthesis and parathyroid hyperplasia.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The Expression of Calcium Sensing Receptor in Normal and Diabetic Rat Eyes.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Parathyroid hormone controls paracellular CaProceedings of the National Academy of Sciences of the United States of America · 2017Article
- The genetics of bone mass and susceptibility to bone diseases.Nature reviews. Rheumatology · 2016Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 2 countries.
Funding
Abstract
purpose of reviewVariations in extracellular calcium level have a large impact on kidney function. Most of the effects seen are attributed to the calcium-sensing receptor (CaSR), a widely expressed G-protein-coupled cell surface protein with an important function in bone mineral homeostasis. The purpose of this review is to recapitulate the novel functional aspects of CaSR. RECENT
findingsResults from mouse models demonstrate important functions for CaSR in various tissues. In the kidney, the main role of CaSR is the regulation of calcium reabsorption in the thick ascending limb, independently of its role on parathyroid hormone secretion. CaSR modulates claudin 14, the gatekeeper of paracellular ion transport in the thick ascending limb that is associated with urinary calcium excretion. One intracellular signaling pathway by which CaSR alters tight junction permeability is the calcineurin-NFAT1c-microRNA-claudin14 axis. SUMMARY: The main function of CaSR in the kidney is the regulation of calcium excretion in the thick ascending limb, independently of parathyroid hormone. CaSR modulates paracellular cation transport by altering expression of the tight junction protein claudin 14. Still more work is needed to fully understand all functions of CaSR in the kidney. Alternative pathways of calcium 'sensing' in the kidney need to be investigated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.