ArticleSmall (Weinheim an der Bergstrasse, Germany)2014
Multiscale patterning of a biomimetic scaffold integrated with composite microspheres.
Article in Small (Weinheim an der Bergstrasse, Germany), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Dexamethasone Long-Term Controlled Release from Injectable Dual-Network Hydrogels with Porous Microspheres Immunomodulation Promotes Bone Regeneration.ACS applied materials & interfaces · 2024Article
- Systemic Cisplatin Does Not Affect the Bone Regeneration Process in a Critical Size Defect Murine Model.ACS biomaterials science & engineering · 2024Article
- Article
- Medicated Hydroxyapatite/Collagen Hybrid Scaffolds for Bone Regeneration and Local Antimicrobial Therapy to Prevent Bone Infections.Pharmaceutics · 2021Article
- Nano-structure of vitronectin/heparin on cell membrane for stimulating single cell in iPSC-derived embryoid body.iScience · 2021Article
- Trends in Bone Metastasis Modeling.Cancers · 2020Review
- An in-silico study of cancer cell survival and spatial distribution within a 3D microenvironment.Scientific reports · 2020Article
- Mimicking the Organic and Inorganic Composition of Anabolic Bone Enhances Human Mesenchymal Stem Cell Osteoinduction and Scaffold Mechanical Properties.Frontiers in bioengineering and biotechnology · 2020Article
- Angiogenesis in Tissue Engineering: As Nature Intended?Frontiers in bioengineering and biotechnology · 2020Review
- Bioinspired Scaffold Action Under the Extreme Physiological Conditions of Simulated Space Flights: Osteogenesis Enhancing Under Microgravity.Frontiers in bioengineering and biotechnology · 2020Article
- Nanostructured Biomaterials for Bone Regeneration.Frontiers in bioengineering and biotechnology · 2020Review
- A biomimetic 3D model of hypoxia-driven cancer progression.Scientific reports · 2019Article
- Biomimetic hydroxyapatite/collagen composite drives bone niche recapitulation in a rabbit orthotopic model.Materials today. Bio · 2019Article
- An elastin-based vasculogenic scaffold promotes marginal islet mass engraftment and function at an extrahepatic site.Journal of immunology and regenerative medicine · 2019Article
- Biomimetic nanoparticles with enhanced affinity towards activated endothelium as versatile tools for theranostic drug delivery.Theranostics · 2018Article
- Myxofibrosarcoma primary cultures: molecular and pharmacological profile.Therapeutic advances in medical oncology · 2017Article
- Investigating the Mechanobiology of Cancer Cell-ECM Interaction Through Collagen-Based 3D Scaffolds.Cellular and molecular bioengineering · 2017Article
- A nanofibrous electrospun patch to maintain human mesenchymal cell stemness.Journal of materials science. Materials in medicine · 2017Article
- Innovative approaches to establish and characterize primary cultures: anBiology open · 2017Article
- Patterning Biomaterials for the Spatiotemporal Delivery of Bioactive Molecules.Frontiers in bioengineering and biotechnology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
The ideal scaffold for regenerative medicine should concurrently mimic the structure of the original tissue from the nano- up to the macroscale and recapitulate the biochemical composition of the extracellular matrix (ECM) in space and time. In this study, a multiscale approach is followed to selectively integrate different types of nanostructured composite microspheres loaded with reporter proteins, in a multi-compartment collagen scaffold. Through the preservation of the structural cues of the functionalized collagen scaffold at the nano- and microscale, its macroscopic features (pore size, porosity, and swelling) are not altered. Additionally, the spatial confinement of the microspheres allows the release of the reporter proteins in each of the layers of the scaffold. Finally, the staged and zero-order release kinetics enables the temporal biochemical patterning of the scaffold. The versatile manufacturing of each component of the scaffold results in the ability to customize it to better mimic the architecture and composition of the tissues and biological systems.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.