ArticleHuman brain mapping2014
Assessment of whole brain white matter integrity in youths and young adults with a family history of substance-use disorders.
Article in Human brain mapping, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 42 citations in OpenAlex.
- Increased forebrain activations in youths with family histories of alcohol and other substance use disorders performing a Go/NoGo task.Alcoholism, clinical and experimental research · 2014Trial
- Family History of Substance Use and Stressful Life Events Impact Adolescent Maturation of Cerebral White Matter.Addiction biology · 2025Article
- Increased white blood cell in young adults with family histories of alcohol and other substance use disorders.Addiction biology · 2024Article
- Neural response to threat and reward among young adults at risk for alcohol use disorder.Addiction biology · 2024Article
- NEURAL RESPONSE TO THREAT AND REWARD AMONG YOUNG ADULTS AT RISK FOR ALCOHOL USE DISORDER.medRxiv : the preprint server for health sciences · 2023Article
- Emotion regulation in young adults with family history of harmful alcohol use: A fMRI study.Drug and alcohol dependence · 2023Article
- Early life adversity and increased antisocial and depressive tendencies in young adults with family histories of alcohol and other substance use disorders: Findings from the Family Health Patterns project.Addictive behaviors reports · 2022Article
- Cannabis, connectivity, and coming of age: Associations between cannabis use and anterior cingulate cortex connectivity during the transition to adulthood.Frontiers in human neuroscience · 2022Article
- Promoting brain health through physical activity among adults exposed to early life adversity: Potential mechanisms and theoretical framework.Neuroscience and biobehavioral reviews · 2021Review
- White matter integrity and functional connectivity in adolescents with a parental history of substance use disorder.Neuroimage. Reports · 2021Article
- White Matter Microstructure in the Young Adult Brain Varies with Neighborhood Disadvantage in Adolescence.Neuroscience · 2021Article
- Neurobiological mechanisms of early life adversity, blunted stress reactivity and risk for addiction.Neuropharmacology · 2021Review
- The Development of Impulsivity and Sensation Seeking: Associations with Substance Use among At-Risk Adolescents.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2020Article
- Blunted stress reactivity reveals vulnerability to early life adversity in young adults with a family history of alcoholism.Addiction (Abingdon, England) · 2019Observational
- Altered frontostriatal white matter microstructure is associated with familial alcoholism and future binge drinking in adolescence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Early life adversity and increased delay discounting: Findings from the Family Health Patterns project.Experimental and clinical psychopharmacology · 2019Article
- Resilience to Risk for Psychopathology: The Role of White Matter Microstructural Development in Adolescence.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Article
- Chronic oxycodone induces axonal degeneration in rat brain.BMC neuroscience · 2018Article
- Miniature pig model of human adolescent brain white matter development.Journal of neuroscience methods · 2018Article
- Global white matter microstructural abnormalities associated with addiction liability score in drug naïve youth.Brain imaging and behavior · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
Individuals with a family history of substance use disorders (FH+) are at a greater risk of developing substance use disorders than their peers with no such family histories (FH-) and this vulnerability is proportional to the number of affected relatives (FH density). The risk for developing substance use disorders peaks during adolescence to early adulthood in the general population, and that is thought to be related to delayed maturation of frontocortical and frontostriatal functional circuits. We hypothesized that FH+ youth and young adults have impaired myelination of frontocortical and frontostriatal white matter tracts. We examined fractional anisotropy (FA) data in 80 FH+ and 34 FH- youths (12.9 ± 1.0 years) and in 25 FH+ and 30 FH- young adults (24.3 ± 3.4 years). FH+ youths had lower FA values in both frontocortical and frontostriatal tracts as well as parietocortical tracts including the anterior, superior and posterior corona radiata and the superior frontal-occipital fasciculus. Moreover, FA values in these tracts were negatively correlated with FH density. FH+ adults had lower FA values in two frontocortical tracts: the genu of the corpus callosum and anterior corona radiata and also significant negative correlations between FA and FH density in these same tracts. In both groups, lower FA values corresponded to higher radial diffusivity suggesting reduced axonal myelination. We interpreted our findings as evidence for impaired myelination of frontal white matter that was proportional to FH density. Our data suggest that deficits may partially resolve with age, paralleling an age-related decline in risk for developing substance use disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.