ArticleJournal of the International Neuropsychological Society : JINS2014
APOE moderates the association between lifestyle activities and cognitive performance: evidence of genetic plasticity in aging.
Article in Journal of the International Neuropsychological Society : JINS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- APOE genotype, hippocampal volume, and cognitive reserve predict improvement by cognitive training in older adults without dementia: a randomized controlled trial.Cognitive processing · 2024Trial
- Alzheimer's disease genetic risk and cognitive reserve in relationship to long-term cognitive trajectories among cognitively normal individuals.Alzheimer's research & therapy · 2023Article
- Data-driven approaches to executive function performance and structure in aging: Integrating person-centered analyses and machine learning risk prediction.Neuropsychology · 2021Article
- The APOE ε4 allele in relation to pre- and postsurgical cognitive functioning of patients with primary brain tumors.European journal of neurology · 2021Article
- Integrating Three Characteristics of Executive Function in Non-Demented Aging: Trajectories, Classification, and Biomarker Predictors.Journal of the International Neuropsychological Society : JINS · 2021Article
- A Multimodal Risk Network Predicts Executive Function Trajectories in Non-demented Aging.Frontiers in aging neuroscience · 2021Article
- APOE effects on cognition from childhood to adolescence.Neurobiology of aging · 2019Article
- Lifespan Intellectual Factors, Genetic Susceptibility, and Cognitive Phenotypes in Aging: Implications for Interventions.Frontiers in aging neuroscience · 2019Review
- Modifiable Risk Factors Discriminate Memory Trajectories in Non-Demented Aging: Precision Factors and Targets for Promoting Healthier Brain Aging and Preventing Dementia.Journal of Alzheimer's disease : JAD · 2019Article
- Childhood socioeconomic status and genetic risk for poorer cognition in later life.Social science & medicine (1982) · 2018Article
- Alzheimer's Biomarkers From Multiple Modalities Selectively Discriminate Clinical Status: Relative Importance of Salivary Metabolomics Panels, Genetic, Lifestyle, Cognitive, Functional Health and Demographic Risk Markers.Frontiers in aging neuroscience · 2018Article
- Memory Resilience to Alzheimer's Genetic Risk: Sex Effects in Predictor Profiles.The journals of gerontology. Series B, Psychological sciences and social sciences · 2017Article
- Cognitive activity mediates the association between social activity and cognitive performance: A longitudinal study.Psychology and aging · 2016Article
- Apolipoprotein E and Clusterin can magnify effects of personality vulnerability on declarative memory performance in non-demented older adults.International journal of geriatric psychiatry · 2016Article
- Genetic Modulation of Neurocognitive Function in Glioma Patients.Clinical cancer research : an official journal of the American Association for Cancer Research · 2015Article
- The BDNF Val66Met polymorphism moderates the relationship between cognitive reserve and executive function.Translational psychiatry · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The current study examined independent and interactive effects between Apolipoprotein E (APOE) genotype and two types of cognitively-stimulating lifestyle activities (CSLA)-integrated information processing (CSLA-II) and novel information processing (CSLA-NI)-on concurrent and longitudinal changes in cognition. Three-wave data across 6 years of follow-up from the Victoria Longitudinal Study (n=278; ages 55-94) and linear mixed model analyses were used to characterize the effects of APOE genotype and participation in CSLA-II and CSLA-NI in four cognitive domains. Significant CSLA effects on cognition were observed. More frequent participation in challenging activities (i.e., CSLA-NI) was associated with higher baseline scores on word recall, fact recall, vocabulary and verbal fluency. Conversely, higher participation in less cognitively-challenging activities (i.e., CSLA-II) was associated with lower scores on fact recall and verbal fluency. No longitudinal CSLA-cognition effects were found. Two significant genetic effects were observed. First, APOE moderated CSLA-II and CSLA-NI associations with baseline verbal fluency and fact recall scores. Second, APOE non-ɛ4 carriers' baseline performance were more likely to be moderated by CSLA participation, compared to APOE-ɛ4 carriers. Our findings suggest APOE may be a "plasticity" gene that makes individuals more or less amenable to the influence of protective factors such as CSLA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.