ArticlePharmaceutical research2014
The acoustic features of inhalation can be used to quantify aerosol delivery from a Diskus™ dry powder inhaler.
Article in Pharmaceutical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Trial
- Trial
- Flowrate Sensing and Measurement in Portable Smart Inhalers.Sensors (Basel, Switzerland) · 2024Review
- Objective Assessment of Adherence and Inhaler Technique among Asthma and COPD Patients in London: A Study in Community Pharmacies Using an Electronic Monitoring Device.Pharmacy (Basel, Switzerland) · 2023Article
- Assessing adherence to inhaled therapies in asthma and the emergence of electronic monitoring devices.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Investigating the Accuracy of the Digihaler, a New Electronic Multidose Dry-Powder Inhaler, in Measuring Inhalation Parameters.Journal of aerosol medicine and pulmonary drug delivery · 2022Article
- The Impact of Biofeedback on Self-Efficacy in Adults with Asthma: A Cross-Sectional Descriptive Survey.Patient preference and adherence · 2022Article
- Digital Inhalers for Asthma or Chronic Obstructive Pulmonary Disease: A Scientific Perspective.Pulmonary therapy · 2021Review
- Understanding Carrier Performance in Low-Dose Dry Powder Inhalation: An In VitroPharmaceutics · 2021Article
- A Clinical Perspective on the Role of Electronic Devices in Monitoring and Promoting Adherence in Airways Disease.Frontiers in medical technology · 2021Article
- Digital technologies and adherence in respiratory diseases: the road ahead.The European respiratory journal · 2018Review
- Identifying Critical Errors: Addressing Inhaler Technique in the Context of Asthma Management.Pulmonary therapy · 2018Review
- Estimation of inhalation flow profile using audio-based methods to assess inhaler medication adherence.PloS one · 2018Article
- Peak Inspiratory Flow Rate in Chronic Obstructive Pulmonary Disease: Implications for Dry Powder Inhalers.Journal of aerosol medicine and pulmonary drug delivery · 2017Review
- Predicting asthma exacerbations employing remotely monitored adherence.Healthcare technology letters · 2016Article
- Towards tailored and targeted adherence assessment to optimise asthma management.NPJ primary care respiratory medicine · 2015Article
- Digital healthcare in COPD management: a narrative review on the advantages, pitfalls, and need for further research.Therapeutic advances in respiratory diseaseReview
- Measuring Peak Inspiratory Flow in Patients with Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary diseaseReview
- Prevalence and factors associated with suboptimal peak inspiratory flow rates in COPD.International journal of chronic obstructive pulmonary diseaseObservational
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSome patients are unable to generate the peak inspiratory flow rate (PIFR) necessary to de-agglomerate drug particles from dry powder inhalers (DPIs). In this study we tested the hypothesis that the acoustic parameters of an inhalation are related to the PIFR and hence reflect drug delivery.
methodsA sensitivity analysis of the relationship of the acoustics of inhalation to simultaneously recorded airflow, in a cohort of volunteers (n = 92) was performed. The Next Generation Impactor (NGI) was used to assess in vitro drug delivery from salmeterol/fluticasone and salbutamol Diskus™ DPIs. Fine particle fraction, FPF, (<5 μm) was measured at 30-90 l/min for 2-6 s and correlated with acoustically determined flow rate (IFRc). In pharmacokinetic studies using a salbutamol (200 μg) Diskus™, volunteers inhaled either at maximal or minimal effort on separate days.
resultsPIFRc was correlated with spirometrically determined values (R (2) = 0.88). In in vitro studies, FPF increased as both flow rate and inhalation duration increased for the salmeterol/fluticasone Diskus™ (Adjusted R (2) = 0.95) and was proportional to flow rate only for the salbutamol Diskus™ (Adjusted R (2) = 0.71). In pharmacokinetic studies, blood salbutamol levels measured at 20 min were significantly lower when PIFRc was less than 60 l/min, p < 0.0001.
conclusionAcoustically-determined PIFR is a suitable method for estimating drug delivery and for monitoring inhalation technique over time.
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Registered trials
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