Evidence map›Paper›PMID 24867353›Full record

Trial reportNeuroImage2014

Intensive cognitive training in schizophrenia enhances working memory and associated prefrontal cortical efficiency in a manner that drives long-term functional gains.

Karuna Subramaniam, Tracy L Luks, Coleman Garrett, Cleo Chung, Melissa Fisher, Srikantan Nagarajan, Sophia Vinogradov

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in NeuroImage, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02920632 (COGTIPS), which is not on this map. Cited by 81 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 6 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02920632 nacompletednot on this mapstarted 2017, after this paper: background citation

COGTIPS (COGnitive Training In Parkinson Study): The Effect of Online Cognitive Training on Cognition and Brain Networks in Parkinson's Disease

TypeinterventionalSponsorAmsterdam UMC, location VUmcRan2017 to 2021Enrolled167ConditionsParkinson Disease, Impaired Cognition, Alteration in CognitionArmsOnline cognitive training 1, Online cognitive training 2
3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 6 syntheses or guidelines pooled it, 147 citations in OpenAlex.

  1. Video games for people with schizophrenia.The Cochrane database of systematic reviews · 2021
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  16. Change in prefrontal activity and executive functions after action-based cognitive remediation in bipolar disorder: a randomized controlled trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Karuna SubramaniamDepartment of Psychiatry, University of California, San Francisco, CA-94121, USA. Electronic address: karuna.subramaniam@ucsf.edu.
Tracy L LuksDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA-94123, USA.
Coleman GarrettDepartment of Psychiatry, University of California, San Francisco, CA-94121, USA.
Cleo ChungUtrecht University, Netherlands.
Melissa FisherDepartment of Psychiatry, University of California, San Francisco, CA-94121, USA.
Srikantan NagarajanDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA-94123, USA.
Sophia VinogradovDepartment of Psychiatry, University of California, San Francisco, CA-94121, USA.
University of California, San Francisco · USUtrecht University · NL

Funding

Cognitive Remediation of Schizophrenia in a Community Mental Health SettingR01MH068725 · NIMH · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI VINOGRADOV, SOPHIA · 2004 to 2014
$4.9M
Neuroscience-Guided Cognitive Remediation in Adolescents at Risk for PsychosisR01MH081051 · NIMH · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI VINOGRADOV, SOPHIA · 2008 to 2012
$2.4M
NIMH NIH HHS R01 MH068725NIMH NIH HHS R01 MH081051NIMH NIH HHS R01MH081051
6 · The paper itself

Abstract

We investigated whether intensive computerized cognitive training in schizophrenia could improve working memory performance and increase signal efficiency of associated middle frontal gyri (MFG) circuits in a functionally meaningful manner. Thirty schizophrenia participants and 13 healthy comparison participants underwent fMRI scanning during a letter N-back working memory task. Schizophrenia participants were then randomly assigned to either 80 h (16 weeks) of cognitive training or a computer games control condition. After this intervention, participants completed a second fMRI N-back scanning session. At baseline, during 2-back working memory trials, healthy participants showed the largest and most significant activation in bilateral MFG, which correlated with task performance. Schizophrenia participants showed impaired working memory, hypoactivation in left MFG, and no correlation between bilateral MFG signal and task performance. After training, schizophrenia participants improved their 2-back working memory performance and showed increased activation in left MFG. They also demonstrated a significant association between enhanced task performance and right MFG signal, similar to healthy participants. Both task performance and brain activity in right MFG after training predicted better generalized working memory at 6-month follow-up. Furthermore, task performance and brain activity within bilateral MFG predicted better occupational functioning at 6-month follow-up. No such findings were observed in the computer games control participants. Working memory impairments in schizophrenia and its underlying neural correlates in MFG can be improved by intensive computerized cognitive training; these improvements generalize beyond the trained task and are associated with enduring effects on cognition and functioning 6 months after the intervention.

Indexed as

Memory, Short-TermAntipsychotic AgentsCognitive Behavioral TherapyDouble-Blind MethodFemaleFrontal LobeGames, ExperimentalGeneralization, PsychologicalHumansMaleMiddle AgedPrefrontal CortexPsychomotor PerformanceSchizophreniaSchizophrenic PsychologyYoung AdultAntipsychotic AgentsCognitive trainingfMRIPrefrontal cortexSchizophreniaWorking memory

Identifiers

PMID24867353
PMCPMC4498800
OpenAlexW2001783963

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.