ArticleeLife2014
Cell elongation is regulated through a central circuit of interacting transcription factors in the Arabidopsis hypocotyl.
Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 314 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
314 citing papers in PubMed, 1 synthesis or guideline pooled it, 625 citations in OpenAlex.
- AGL15 Promotion of Somatic Embryogenesis: Role and Molecular Mechanism.Frontiers in plant science · 2022Pooled it
- Structural variation in the IAMH2 3' UTR underlies hypocotyl elongation during light adaptation in Arabidopsis thaliana.The Plant journal : for cell and molecular biology · 2026Article
- AUXIN RESPONSE FACTORs: from transcription factors to auxin effectors.The New phytologist · 2026Review
- Brassinosteroids promote sugar synthesis by inhibiting BIN2 phosphorylation of phosphoenolpyruvate carboxykinase.Nature plants · 2026Article
- Brassinosteroids as Central Regulators of Plant Growth, Stress Tolerance, and Agricultural Resilience.Plants (Basel, Switzerland) · 2026Review
- Shaping Plant Adaptation in a Warmer World: Developmental Plasticity Under Moderately Elevated Temperatures.Plants (Basel, Switzerland) · 2026Review
- DELLA proteins interact with HAC1 and control plant growth via transcriptional regulation of the growth repressor gene ERF2.The Plant cell · 2026Article
- Towards an integrated molecular understanding of plant hormones.Journal of integrative plant biology · 2026Review
- A two-step auxin-GA cross-talk regulates organ formation in tomato.Development (Cambridge, England) · 2026Article
- The transcription elongation factor IWS1 promotes thermomorphogenesis by integrating the brassinosteroid and gibberellin pathways in Arabidopsis.Plant communications · 2026Article
- Hexokinase 1 facilitates post-germinative seedling growth through its catalytic function.The Plant journal : for cell and molecular biology · 2026Article
- From signals to solutions: stress-induced leaf senescence and synthetic biology and AI approaches for crop resilience.Molecular horticulture · 2026Review
- Genome-wide modelling of plant transcription factor binding captures regulatory variants associated with phenotypic traits.Nature communications · 2026Article
- ARF6 integrates auxin and gibberellin signaling to promote stone cell lignification in pear via the HB49-MYB169 module.The New phytologist · 2026Article
- Complex Interplay of Tandem, Segmental, Whole Genome Duplication, and Re-organization Drives Expansion of SAUR Gene Family in Brassicaceae.Biochemical genetics · 2026Article
- Transient cell states encode positional information to direct asymmetric growth.bioRxiv : the preprint server for biology · 2026Article
- Plant movements: navigating the light environment.Plant physiology · 2026Review
- Brassinosteroids control cell proliferation in the lateral root cap of the Arabidopsis root.EMBO reports · 2026Article
- DNA Methylation Fine-Tunes Light- and Hormone-Responsive Growth Plasticity inInternational journal of molecular sciences · 2026Article
- The multifaceted role of gibberellins in somatic embryogenesis: fromFrontiers in plant science · 2026Review
254 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
As the major mechanism of plant growth and morphogenesis, cell elongation is controlled by many hormonal and environmental signals. How these signals are coordinated at the molecular level to ensure coherent cellular responses remains unclear. In this study, we illustrate a molecular circuit that integrates all major growth-regulating signals, including auxin, brassinosteroid, gibberellin, light, and temperature. Analyses of genome-wide targets, genetic and biochemical interactions demonstrate that the auxin-response factor ARF6, the light/temperature-regulated transcription factor PIF4, and the brassinosteroid-signaling transcription factor BZR1, interact with each other and cooperatively regulate large numbers of common target genes, but their DNA-binding activities are blocked by the gibberellin-inactivated repressor RGA. In addition, a tripartite HLH/bHLH module feedback regulates PIFs and additional bHLH factors that interact with ARF6, and thereby modulates auxin sensitivity according to developmental and environmental cues. Our results demonstrate a central growth-regulation circuit that integrates hormonal, environmental, and developmental controls of cell elongation in Arabidopsis hypocotyl.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.