Evidence map›Paper›PMID 24867183›Full record

Trial reportPloS one2014

Prevalence and clinical relevance of T-helper cells, Th17 and Th1, in hepatitis B virus-related hepatocellular carcinoma.

Jian Yan, Xiao-Long Liu, Gang Xiao, Ning-Lei Li, Yi-Nan Deng, Lu-Zhe Han, Liang-Chun Yin, Li-Juan Ling, Li-Xin Liu

Open access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

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  10. T cells in health and disease.Signal transduction and targeted therapy · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jian YanDepartment of General Surgery, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China.
Xiao-Long LiuDepartment of General Surgery, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China.
Gang XiaoDepartment of General Surgery, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China.
Ning-Lei LiDepartment of General Surgery, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China.
Yi-Nan DengGuangdong Provincial Key Laboratory of Liver Disease Research, Guangzhou, China; Department of Hepatic Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Lu-Zhe HanDepartment of General Surgery, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China.
Liang-Chun YinDepartment of General Surgery, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China.
Li-Juan LingDepartment of General Surgery, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China.
Li-Xin LiuDepartment of General Surgery, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China.
Third Affiliated Hospital of Southern Medical University · CNThird Affiliated Hospital of Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsAn immune imbalance in the cytokine profile exerts a profound influence on the progression of hepatitis B virus (HBV) infections and hepatocellular carcinoma (HCC). The present study evaluated the immune status of T helper (Th) 17 and Th1 cells in patients with HBV-related and non-HBV-related HCC.

methodsWe randomly enrolled 150 patients with HCC. Blood samples and tissue samples were obtained. The distributions and phenotypic features of Th17 and Th1 cells were determined by flow cytometry and/or immunohistochemistry.

resultsCompared to corresponding non-tumor regions, the levels of Th17 and Th1 cells were significantly increased in tumors of patients with HCC (P<0.001). The intratumoral densities of IL-17-producing cells and IFN-γ-producing cells were associated with overall survival (OS, P = 0.001) and disease-free survival (DFS, P = 0.001) of patients with HCC. The ratio of Th17 to Th1 in HBV-related HCC was higher than in non-HBV-related HCC. A multivariate Cox analysis revealed that the Th17 to Th1 ratio was an independent prognostic factor for OS (HR = 2.651, P = 0.007) and DFS (HR = 2.456, P = 0.002).

conclusionsHBV infections can lead to an imbalance in immune status in patients with HCC. An elevated Th17 to Th1 ratio may promote tumor progression. The Th17 to Th1 ratio could serve as a potential prognostic marker for scoring the severity of HCC.

Indexed as

Carcinoma, HepatocellularCase-Control StudiesCytokinesDisease ProgressionFlow CytometryFollow-Up StudiesHepatitis BHepatitis B virusHumansImmunoenzyme TechniquesInterleukin-17Liver NeoplasmsPrognosisSurvival RateTh17 CellsTh1 CellsCytokinesInterleukin-17

Identifiers

PMID24867183
PMCPMC4035251
OpenAlexW2001760397

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.