ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2014
Concentration-dependent effects of WNTLESS on WNT1/3A signaling.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 citing papers in PubMed, 9 citations in OpenAlex.
- Wnt signalling facilitates neuronal differentiation of cochlear Frizzled10-positive cells in mouse cochlea via glypican 6 modulation.Cell communication and signaling : CCS · 2025Article
- Direct visualization of the Wntless-induced redistribution of WNT1 in developing chick embryos.Developmental biology · 2018Article
- Divergent effects of Porcupine and Wntless on WNT1 trafficking, secretion, and signaling.Experimental cell research · 2016Article
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6 authors at 1 institution in 1 country.
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Abstract
backgroundWNTLESS (WLS) is a multi-transmembrane protein that transports Wnt ligands from the Golgi to the cell surface. Although WLS loss-of-function experiments in the developing central nervous system reveal phenotypes consistent with defects in WNT1 and WNT3A signaling, data from complementary gain-of-function experiments have not yet been reported. Here, we report the phenotypic consequences of WLS overexpression in cultured cells and in the developing chick spinal cord.
resultsOverexpression of small amounts of WLS along with either WNT1 or WNT3A promotes the Wnt/β-catenin pathway in HEK293T cells, while overexpression of higher levels of WLS inhibits the Wnt/β-catenin pathway in these cells. Similarly, overexpressed WLS inhibits the Wnt/β-catenin pathway in the developing spinal cord, as assessed by cell proliferation and specification. These effects appear to be Wnt-specific as overexpression of WLS inhibits the expression of FZD10, a target of β-catenin-dependent transcription.
conclusionsOur results show that overexpression of WLS inhibits Wnt/β-catenin signaling in the spinal cord. As the activation of the Wnt/β-catenin pathway in the spinal cord requires WNT1 or WNT3A, our results are consistent with a model in which the relative concentration of WLS to Wnt regulates WNT1/3A signaling in the developing spinal cord.
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