Evidence map›Paper›PMID 24866828›Full record

ArticleJournal of the American Chemical Society2014

Isoprenoid phosphonophosphates as glycosyltransferase acceptor substrates.

Mario A Martinez Farias, Virginia A Kincaid, Venkatachalam R Annamalai, Laura L Kiessling

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Biosynthesis of Galactan inAntibiotics (Basel, Switzerland) · 2020
    Review
  4. Article
  5. Bacterial Cell Wall Modification with a Glycolipid Substrate.Journal of the American Chemical Society · 2019
    Article
  6. Article
  7. Comparing Galactan Biosynthesis inThe Journal of biological chemistry · 2017
    Article
  8. Review
  9. Fidelity and Promiscuity of a Mycobacterial Glycosyltransferase.Journal of the American Chemical Society · 2016
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mario A Martinez FariasDepartment of Chemistry and ‡Department of Biochemistry, University of Wisconsin-Madison , Madison, Wisconsin 53706, United States.
Virginia A Kincaid
Venkatachalam R Annamalai
Laura L Kiessling
University of Wisconsin–Madison · US

Funding

The Chemistry and Biology of Galactofuranose ResiduesR01AI063596 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KIESSLING, LAURA L · 2005 to 2014
$3.0M
Chemical Biology Studies of the Essential Mycobacterial Enzyme GifTF32GM084475 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI ANNAMALAI, VENKATACHALAM RAJA · 2007 to 2009
$141k
Study Of Mycobacterial Galactan Biosynthesis By Chemoenzymatic Substrate AssemblyF31GM101953 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI MARTINEZ FARIAS, MARIO A · 2012 to 2014
$59k
NIAID NIH HHS R01 AI063596NIAID NIH HHS R01-AI063596NIGMS NIH HHS F31 GM101953NIGMS NIH HHS F32 GM084475
6 · The paper itself

Abstract

Glycosyltransferases that act on polyprenol pyrophosphate substrates are challenging to study because their lipid-linked substrates are difficult to isolate from natural sources and arduous to synthesize. To facilitate access to glycosyl acceptors, we assembled phosphonophosphate analogues and showed these are effective substrate surrogates for GlfT1, the essential product of mycobacterial gene Rv3782. Under chemically defined conditions, the galactofuranosyltransferase GlfT1 catalyzes the formation of a tetrasaccharide sequence en route to assembly of the mycobacterial galactan.

Indexed as

BiocatalysisGlycosyltransferasesMolecular StructurePolyisoprenyl PhosphatesSubstrate SpecificityGlycosyltransferasesPolyisoprenyl Phosphates

Identifiers

PMID24866828
PMCPMC4073833
OpenAlexW2330883027

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.