ArticleInfection and immunity2014
Deep sequencing analysis reveals temporal microbiota changes associated with development of bovine digital dermatitis.
Article in Infection and immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
71 citing papers in PubMed, 1 synthesis or guideline pooled it, 142 citations in OpenAlex.
- Meta-Analysis of Bovine Digital Dermatitis Microbiota Reveals Distinct Microbial Community Structures Associated With Lesions.Frontiers in cellular and infection microbiology · 2021Pooled it
- Bos indicus cattle resistant to digital dermatitis exhibit a balanced proinflammatory cytokine response upon exposure to Treponema phagedenis in contrast to Bos taurus cattle.Veterinary research · 2026Article
- Effect ofMicrobiology spectrum · 2026Article
- Do Treponemes in Bovine Digital Dermatitis-Associated Claw Horn Lesions Preclude Co-Infection by Pyogenic Bacteria?Microorganisms · 2026Article
- An experimental infection model for rapid reproduction of treponeme-associated hoof disease in captive elk (Microbiology spectrum · 2026Article
- Global Analysis of the Co-Occurrence of Antimicrobial and Metal Resistance Genes in Bacterial Genomes From Dairy-Isolated Pathogens.Environmental microbiology · 2026Article
- Altered splenic T-cell subpopulation dynamics in a murine model of bovine digital dermatitis-associatedFrontiers in immunology · 2026Article
- Bacterial community analysis of treponeme-associated hoof disease in free-ranging elk (Applied and environmental microbiology · 2025Article
- Proteolytic dysfunction in bovine digital dermatitis caused by Treponema spp. and the therapeutic use of non-antimicrobial matrix metalloproteinase inhibitors.Communications biology · 2025Article
- Molecular detection and distribution of Treponema species in a commercial dairy cattle herd in Slovakia.Veterinary research communications · 2025Article
- Profiling bacterial communities in feedlot cattle affected with bovine foot rot and bovine digital dermatitis lesions using 16S rRNA gene sequencing and quantitative real-time PCR.BMC microbiology · 2025Article
- The Effect ofAnimals : an open access journal from MDPI · 2024Article
- Metabolic Footprint ofPathogens (Basel, Switzerland) · 2024Article
- Characterization of the Hoof Bacterial Communities of Active Digital Dermatitis Lesions in Feedlot Cattle.Microorganisms · 2024Article
- Discovery of novel treponemes associated with pododermatitis in elk (Applied and environmental microbiology · 2024Article
- Digital dermatitis in Swedish dairy herds assessed by ELISA targeting Treponema phagedenis in bulk tank milk.BMC veterinary research · 2024Article
- Correlation of lesion severity with bacterial changes in Treponeme-Associated Hoof Disease from free-roaming wild elk (Cervus canadensis).Animal microbiome · 2024Article
- Epidemiology of Digital Dermatitis in Western Canadian Feedlot Cattle.Animals : an open access journal from MDPI · 2024Article
- Proinflammatory CD14Infection and immunity · 2024Article
- Local and Systemic Inflammation in Finnish Dairy Cows with Digital Dermatitis.Animals : an open access journal from MDPI · 2024Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bovine digital dermatitis (DD) is a leading cause of lameness in dairy cattle throughout the world. Despite 35 years of research, the definitive etiologic agent associated with the disease process is still unknown. Previous studies have demonstrated that multiple bacterial species are associated with lesions, with spirochetes being the most reliably identified organism. This study details the deep sequencing-based metagenomic evaluation of 48 staged DD biopsy specimens collected during a 3-year longitudinal study of disease progression. Over 175 million sequences were evaluated by utilizing both shotgun and 16S metagenomic techniques. Based on the shotgun sequencing results, there was no evidence of a fungal or DNA viral etiology. The bacterial microbiota of biopsy specimens progresses through a systematic series of changes that correlate with the novel morphological lesion scoring system developed as part of this project. This scoring system was validated, as the microbiota of each stage was statistically significantly different from those of other stages (P < 0.001). The microbiota of control biopsy specimens were the most diverse and became less diverse as lesions developed. Although Treponema spp. predominated in the advanced lesions, they were in relatively low abundance in the newly described early lesions that are associated with the initiation of the disease process. The consortium of Treponema spp. identified at the onset of disease changes considerably as the lesions progress through the morphological stages identified. The results of this study support the hypothesis that DD is a polybacterial disease process and provide unique insights into the temporal changes in bacterial populations throughout lesion development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.