ReviewNature reviews. Genetics2014
The dawn of evolutionary genome engineering.
Review in Nature reviews. Genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Article
- A Protocol for the Automatic Construction of Highly Curated Genome-Scale Models of Human Metabolism.Bioengineering (Basel, Switzerland) · 2023Article
- Greedy reduction of Bacillus subtilis genome yields emergent phenotypes of high resistance to a DNA damaging agent and low evolvability.Nucleic acids research · 2023Article
- Research progress of pathway and genome evolution in microbes.Synthetic and systems biotechnology · 2022Article
- Methods for measuring the evolutionary stability of engineered genomes to improve their longevity.Synthetic biology (Oxford, England) · 2021Article
- Experimental Challenges for Reduced Genomes: The Cell ModelMicroorganisms · 2019Review
- Functional Constraints on Replacing an Essential Gene with Its Ancient and Modern Homologs.mBio · 2017Article
- An evolutionary optimization of a rhodopsin-based phototrophic metabolism in Escherichia coli.Microbial cell factories · 2017Article
- Correlation between genome reduction and bacterial growth.DNA research : an international journal for rapid publication of reports on genes and genomes · 2016Article
- A highly precise and portable genome engineering method allows comparison of mutational effects across bacterial species.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Overcoming Challenges in Engineering the Genetic Code.Journal of molecular biology · 2016Review
- Uncovering the Genetic Architectures of Quantitative Traits.Computational and structural biotechnology journal · 2016Review
- The LASER database: Formalizing design rules for metabolic engineering.Metabolic engineering communications · 2015Article
- Targeted Large-Scale Deletion of Bacterial Genomes Using CRISPR-Nickases.ACS synthetic biology · 2015Article
- DNA nanotechnology: new adventures for an old warhorse.Current opinion in chemical biology · 2015Review
- Genomes by design.Nature reviews. Genetics · 2015Review
- Multiplexed tracking of combinatorial genomic mutations in engineered cell populations.Nature biotechnology · 2015Article
- Genome instability mediates the loss of key traits by Acinetobacter baylyi ADP1 during laboratory evolution.Journal of bacteriology · 2015Article
- Article
- Genetic manipulation of reptilian embryos: toward an understanding of cortical development and evolution.Frontiers in neuroscience · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Genome engineering strategies--such as genome editing, reduction and shuffling, and de novo genome synthesis--enable the modification of specific genomic locations in a directed and combinatorial manner. These approaches offer an unprecedented opportunity to study central evolutionary issues in which natural genetic variation is limited or biased, which sheds light on the evolutionary forces driving complex and extremely slowly evolving traits; the selective constraints on genome architecture; and the reconstruction of ancestral states of cellular structures and networks.
Indexed as
Identifiers
24866756What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.