ArticleProtein & cell2014
Characterization of human αβTCR repertoire and discovery of D-D fusion in TCRβ chains.
Article in Protein & cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Quantitative characterization of T-cell repertoire in allogeneic hematopoietic stem cell transplant recipients.Bone marrow transplantation · 2015Trial
- scTCR-seq and HTS reveal a special novel TRBD2-TRBJ1 rearrangement in mammalian TRB CDR3 repertoire.BMC genomics · 2025Article
- A pooled CRISPR screen identifies the Tα2 enhancer element as a driver ofFrontiers in immunology · 2025Article
- Exploring COVID-19 causal genes through disease-specific Cis-eQTLs.Virus research · 2024Article
- Whole-Exome Sequencing and Analysis of the T Cell Receptor β and γ Repertoires in Rheumatoid Arthritis.Diagnostics (Basel, Switzerland) · 2024Article
- Novel bimodal TRBD1-TRBD2 rearrangements with dual or absent D-region contribute to TRB V-(D)-J combinatorial diversity.Frontiers in immunology · 2023Article
- Identification of TRDV-TRAJ V domains in human and mouse T-cell receptor repertoires.Frontiers in immunology · 2023Article
- Identification of TCR repertoires in asymptomatic COVID-19 patients by single-cell T-cell receptor sequencing.Blood cells, molecules & diseases · 2022Article
- Combined presentation and immunogenicity analysis reveals a recurrent RAS.Q61K neoantigen in melanoma.The Journal of clinical investigation · 2021Article
- Article
- Partial recovery of disturbed V-J pairing profiles of T-cell receptor in people living with HIV receiving long-term antiretroviral therapy.Science China. Life sciences · 2021Article
- The Immune Microenvironment in Brain Metastases of Non-Small Cell Lung Cancer.Frontiers in oncology · 2021Review
- V(DD)J recombination is an important and evolutionarily conserved mechanism for generating antibodies with unusually long CDR3s.Genome research · 2020Article
- Comparative analysis of CDR3 regions in paired human αβ CD8 T cells.FEBS open bio · 2019Article
- Next generation sequencing reveals changes of the γδ T cell receptor repertoires in patients with pulmonary tuberculosis.Scientific reports · 2018Article
- Article
- Conserved Vδ1 Binding Geometry in a Setting of Locus-Disparate pHLA Recognition by δ/αβ T Cell Receptors (TCRs): Insight into Recognition of HIV Peptides by TCRs.Journal of virology · 2017Article
- T-cell immunity of SARS-CoV: Implications for vaccine development against MERS-CoV.Antiviral research · 2017Review
- Analyzing the CDR3 Repertoire with respect to TCR-Beta Chain V-D-J and V-J Rearrangements in Peripheral T Cells using HTS.Scientific reports · 2016Article
- Public T cell receptors confer high-avidity CD4 responses to HIV controllers.The Journal of clinical investigation · 2016Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The characterization of the human T-cell receptor (TCR) repertoire has made remarkable progress, with most of the work focusing on the TCRβ chains. Here, we analyzed the diversity and complexity of both the TCRα and TCRβ repertoires of three healthy donors. We found that the diversity of the TCRα repertoire is higher than that of the TCRβ repertoire, whereas the usages of the V and J genes tended to be preferential with similar TRAV and TRAJ patterns in all three donors. The V-J pairings, like the V and J gene usages, were slightly preferential. We also found that the TRDV1 gene rearranges with the majority of TRAJ genes, suggesting that TRDV1 is a shared TRAV/DV gene (TRAV42/DV1). Moreover, we uncovered the presence of tandem TRBD (TRB D gene) usage in ~2% of the productive human TCRβ CDR3 sequences.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.