ArticleAnnals of biomedical engineering2014
Transmural variation and anisotropy of microvascular flow conductivity in the rat myocardium.
Article in Annals of biomedical engineering, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Multicompartment Darcy Flow Model With Patient-Specific Parameterization: Effect of Heterogeneity and Anisotropy in Porous Parameters.International journal for numerical methods in biomedical engineering · 2025Article
- Modeling cardiac microcirculation for the simulation of coronary flow and 3D myocardial perfusion.Biomechanics and modeling in mechanobiology · 2024Article
- A Hybrid Model for Cardiac Perfusion: Coupling a Discrete Coronary Arterial Tree Model with a Continuous Porous-Media Flow Model of the Myocardium.Entropy (Basel, Switzerland) · 2023Article
- Anisotropic Cardiac Conduction.Arrhythmia & electrophysiology review · 2020Review
- Dynamic Changes in Microvascular Flow Conductivity and Perfusion After Myocardial Infarction Shown by Image-Based Modeling.Journal of the American Heart Association · 2019Article
- Brain Capillary Networks Across Species: A few Simple Organizational Requirements Are Sufficient to Reproduce Both Structure and Function.Frontiers in physiology · 2019Article
- Simulation of the Perfusion of Contrast Agent Used in Cardiac Magnetic Resonance: A Step Toward Non-invasive Cardiac Perfusion Quantification.Frontiers in physiology · 2019Article
- Article
- Microvessel Chaste: An Open Library for Spatial Modeling of Vascularized Tissues.Biophysical journal · 2017Article
- Microvascular hemodynamics in the chick chorioallantoic membrane.Microcirculation (New York, N.Y. : 1994) · 2016Article
- Multiphysics and multiscale modelling, data-model fusion and integration of organ physiology in the clinic: ventricular cardiac mechanics.Interface focus · 2016Review
- Structure-based algorithms for microvessel classification.Microcirculation (New York, N.Y. : 1994) · 2015Article
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Authors and funding
6 authors.
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Abstract
Transmural variations in the relationship between structural and fluid transport properties of myocardial capillary networks are determined via continuum modeling approaches using recent three-dimensional (3D) data on the microvascular structure. Specifically, the permeability tensor, which quantifies the inverse of the blood flow resistivity of the capillary network, is computed by volume-averaging flow solutions in synthetic networks with geometrical and topological properties derived from an anatomically-detailed microvascular data set extracted from the rat myocardium. Results show that the permeability is approximately ten times higher in the principal direction of capillary alignment (the "longitudinal" direction) than perpendicular to this direction, reflecting the strong anisotropy of the microvascular network. Additionally, a 30% increase in capillary diameter from subepicardium to subendocardium is shown to translate to a 130% transmural rise in permeability in the longitudinal capillary direction. This result supports the hypothesis that perfusion is preferentially facilitated during diastole in the subendocardial microvasculature to compensate for the severely-reduced systolic perfusion in the subendocardium.
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