Trial reportEmotion (Washington, D.C.)2014
The amygdala mediates the emotional modulation of threat-elicited skin conductance response.
Trial report in Emotion (Washington, D.C.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Neural correlates of negative aesthetic evaluations in visual art: a neuroimaging meta-analysis.Cerebral cortex (New York, N.Y. : 1991) · 2025Pooled it
- The Impact of Stimulus Presentation on Skin Conductance and Potential Implications for Neurofeedback Studies.Applied psychophysiology and biofeedback · 2026Article
- Fight, Flight, or Vote Right? A Systematic Review of Threat Sensitivity in Political Conservatism.Brain sciences · 2025Review
- It's all connected! Multivariate pattern analysis of inter-network connectivity distinguishes between reappraisal and passive viewing of emotional scenes.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Perceptual Sensitivity to Tactile Stimuli Is Enhanced When One Is Aware That Tactile Stimulus Intensity Is Self-Controlled.Brain sciences · 2025Article
- Effect of Neutral and Negative Images on Galvanic Skin Response: An Activity for Courses in Forensic, Affective, and Behavioral Neuroscience.Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2025Article
- Low-intensity transcranial focused ultrasound of the amygdala modulates neural activation during emotion processing.Frontiers in neuroimaging · 2025Article
- The neurophysiological consequences of racism-related stressors in Black Americans.Neuroscience and biobehavioral reviews · 2024Review
- Stress-induced Changes in Autonomic Reactivity Vary with Adolescent Violence Exposure and Resting-state Functional Connectivity.Neuroscience · 2023Article
- Fear memory in humans is consolidated over time independently of sleep.Cognitive, affective & behavioral neuroscience · 2023Article
- Getting Better with Age? A Review of Psychophysiological Studies of Fear Extinction Learning Across Development.Current topics in behavioral neurosciences · 2023Review
- Sex-related differences in violence exposure, neural reactivity to threat, and mental health.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Mind the social feedback: effects of tDCS applied to the left DLPFC on psychophysiological responses during the anticipation and reception of social evaluations.Social cognitive and affective neuroscience · 2022Article
- Prefrontal tDCS Attenuates Self-Referential Attentional Deployment: A Mechanism Underlying Adaptive Emotional Reactivity to Social-Evaluative Threat.Frontiers in human neuroscience · 2021Article
- Sympathetic Response to Postural Perturbation in Stance.Frontiers in human neuroscience · 2021Article
- Violence exposure, affective style, and stress-induced changes in resting state functional connectivity.Cognitive, affective & behavioral neuroscience · 2020Article
- Negative life experiences contribute to racial differences in the neural response to threat.NeuroImage · 2019Article
- Parental Reactivity to Disruptive Behavior in Toddlerhood: An Experimental Study.Journal of abnormal child psychology · 2019Article
- Amygdala and prefrontal cortex activity varies with individual differences in the emotional response to psychosocial stress.Behavioral neuroscience · 2019Article
- The central extended amygdala in fear and anxiety: Closing the gap between mechanistic and neuroimaging research.Neuroscience letters · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The ability to respond adaptively to threats in a changing environment is an important emotional function. The amygdala is a critical component of the neural circuit that mediates many emotion-related processes, and thus likely plays an important role in modulating the peripheral emotional response to threat. However, prior research has largely focused on the amygdala's response to stimuli that signal impending threat, giving less attention to the amygdala's response to the threat itself. From a functional perspective, however, it is the response to the threat itself that is most biologically relevant. Thus, understanding the factors that influence the amygdala's response to threat is critical for a complete understanding of adaptive emotional processes. Therefore, we used functional MRI to investigate factors (i.e., valence and arousal of co-occurring visual stimuli) that influence the amygdala's response to threat (loud white noise). We also assessed whether changes in amygdala activity varied with the peripheral expression of emotion (indexed via skin conductance response; SCR). The results showed that threat-elicited amygdala activation varied with the arousal, not valence, of emotional images. More specifically, threat-elicited amygdala activation was larger to the threat when presented during high-arousal (i.e., negative and positive) versus low-arousal (i.e., neutral) images. Further, the threat-elicited amygdala response was positively correlated with threat-elicited SCR. These findings indicate the amygdala's response to threat is modified by the nature (e.g., arousal) of other stimuli in the environment. In turn, the amygdala appears to mediate important aspects of the peripheral emotional response to threat.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.