Evidence map›Paper›PMID 24866424›Full record

ReviewNature reviews. Cardiology2014

Contemporary overview and clinical perspectives of chronic total occlusions.

Loes P Hoebers, Bimmer E Claessen, George D Dangas, Truls Råmunddal, Roxana Mehran, José P S Henriques

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 44 citations in OpenAlex.

  1. Trial
  2. Association of total Q/R ratio with myocardial scar in patients with chronic total occlusion.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. A Review of Indications and Guidelines of Chronic Total Occlusion Revascularization.The International journal of angiology : official publication of the International College of Angiology, Inc · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Completeness of revascularisation in acute coronary syndrome patients with multivessel disease.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2021
    Article
  13. Article
  14. Incidence and outcomes of chronic total occlusion percutaneous coronary intervention in the Netherlands: data from a nationwide registry.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2021
    Article
  15. Article
  16. Article
  17. Article
  18. Observational
  19. Article
  20. Knowledge of chronic total occlusion among Polish interventional cardiologists.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Loes P HoebersAcademic Medical Center, University of Amsterdam, Department of Cardiology, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands.
Bimmer E ClaessenAcademic Medical Center, University of Amsterdam, Department of Cardiology, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands.
George D DangasMount Sinai Medical Center, Department of Cardiology, One Gustave L. Levy Place, New York, NY 10029, USA.
Truls RåmunddalSahlgrenska University Hospital, Department of Cardiology, Per Dubbsgatan 15, 413 45 Gothenburg, Sweden.
Roxana MehranMount Sinai Medical Center, Department of Cardiology, One Gustave L. Levy Place, New York, NY 10029, USA.
José P S HenriquesAcademic Medical Center, University of Amsterdam, Department of Cardiology, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands.
Amsterdam UMC Location University of Amsterdam · NLMount Sinai Hospital · USSahlgrenska University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic total occlusions (CTOs) are often detected on diagnostic coronary angiograms, but percutaneous coronary intervention (PCI) for CTO is currently infrequently performed owing to high technical difficulty, perceived risk of complications, and a lack of randomized data. However, successful CTO-PCI can significantly increase a patient's quality of life, improve left ventricular function, reduce the need for subsequent CABG surgery, and possibly improve long-term survival. A number of factors must be taken into account for the selection of patients for CTO-PCI, including the extent of ischaemia surrounding the occlusion, the level of myocardial viability, coronary location of the CTO, and probability of procedural success. Moreover, in patients with ST-segment elevation myocardial infarction, a CTO in a noninfarct-related artery might lead to an increase in infarct area, increased end-diastolic left ventricular pressure, and decreased left ventricular function, which are all associated with poor clinical outcomes. In this Review, we provide an overview of the anatomy and histopathology of CTOs, perceived benefits of CTO-PCI, considerations for patient selection for this procedure, and a summary of emerging techniques for CTO-PCI.

Indexed as

Percutaneous Coronary InterventionChronic DiseaseCoronary OcclusionHumansPatient SelectionTreatment Outcome

Identifiers

PMID24866424
OpenAlexW2062398036

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.